Caution is advised when consuming alcohol with Ckemia 4. Please consult your doctor.
UNSAFE
May cause fetal harm
UNSAFE
Breastfeeding not recommended until one week after the final dose.
CAUTION
It is not known whether Ckemia 4 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Ckemia 4 is safe to use in patients with kidney disease. No dose adjustment of Ckemia 4 is recommended.
SAFE IF PRESCRIBED
Ckemia 4 should be used with caution in patients with severe liver disease. Dose adjustment of Ckemia 4 may be needed. Please consult your doctor. A lower dose may be advised in patients with liver disease and who have to take this medicine for a lon...
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Medicine Overview of Ckemia 4mg tablet
Introduction
_NAME_ is a hypoxia-inducible factor, prolyl hydroxylase inhibitor (HIF-PHI). The activity of HIF-PH enzymes controls intracellular levels of HIF, a transcription factor that regulates the expression of genes involved in erythropoiesis. Activation of...
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Uses of Ckemia 4
Ckemia 4 is indicated for the treatment of anemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least four months. Ckemia 4 is not indicated for use: As a substitute for red blood cell transfusions in patients ...
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Side effects of Ckemia 4
Risk of hospitalization due to heart failure High blood pressure damage to the lining of the stomach, the tube that connects the mouth and stomach (esophagus), and intestines (gastrointestinal erosion).
How to use Ckemia 4
Ckemia 4 is to be taken orally.Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it.
How Ckemia 4 works
_NAME_ is a hypoxia-inducible factor, prolyl hydroxylase inhibitor (HIF-PHI). The activity of HIF-PH enzymes controls intracellular levels of HIF, a transcription factor that regulates the expression of genes involved in erythropoiesis. Activation of...
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What if you forget to take Ckemia 4?
If you miss a dose of _NAME_ Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Brief Description
Indication
_NAME_ is indicated for the treatment of anemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least four month...
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Administration
_NAME_ is available in 1,2,4,6 and 8-mg tablet formulations administered orally once daily, with or without food.
Adult Dose
Adults Not Being Treated with an Erythropoiesis-Stimulating Agent (ESA):
Pre-Treatment Hemoglobin Level less than 9 g/dL: 4 mg orally once daily
Pre-...
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Child Dose
Not recommended for children.
Renal Dose
Steady-state exposure of _NAME_ is similar in patients with normal renal function and those with varying degrees of renal impairment
Hemodialysis or p...
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Contraindication
Receiving a strong CYP2C8 inhibitor such as gemfibrozil.
With uncontrolled hypertension.
Mode of Action
-NAME_ is a reversible inhibitor of the hypoxia-inducible factors (HIFs) polyhomeotic-like proteins 1 to 3 (IC50 in the low-nanomoles range), a set of...
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Side Effect
Risk of hospitalization due to heart failure
High blood pressure
Damage to the lining of the stomach, the tube that connects the mouth and stomach (es...
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Pregnancy Category Note
Not recommended in pregnancy. This drug resulted in fetal adverse outcomes in animal study.
Interaction
CYP2C8 Inhibitors: Concomitant administration of strong CYP2C8 inhibitors (e.g., gemfibrozil) with _NAME_ is contraindicated due to a marked increase ...
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ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.