Introduction

Sexually Transmitted Infections (STIs) are a pervasive global health concern, silently affecting millions every day. This article endeavors to provide a thorough exploration of the key facts, the expansive scope of the problem, preventive strategies, diagnostic challenges, effective treatments, and ongoing efforts to control the spread of STIs.

Key Facts About STIs

STIs are alarmingly prevalent, with over 1 million new infections reported daily, a majority of which are asymptomatic. Annually, this toll escalates to a staggering 374 million new cases, prominently featuring chlamydia, gonorrhoea, syphilis, and trichomoniasis. Additionally, genital herpes and human papillomavirus (HPV) contribute significantly to health complications, including cervical cancer.

Scope of the Problem

The impact of STIs extends far beyond immediate health concerns. They elevate the risk of HIV acquisition, contribute to adverse birth outcomes, and can result in cancers, infertility, and pregnancy complications. The emergence of new infections, such as monkeypox, Shigella sonnei, Neisseria meningitidis, Ebola, and Zika, alongside the re-emergence of neglected STIs like lymphogranuloma venereum, adds complexity to prevention and control efforts.

Prevention Strategies

Correct and consistent condom use remains one of the most effective methods to prevent STIs, including HIV. Vaccines for hepatitis B and HPV have marked significant advancements in prevention. By the end of 2020, the HPV vaccine had been introduced as part of routine immunization programs in 111 countries, primarily high- and middle-income countries. Ongoing research targets vaccines for other STIs like genital herpes and HIV.

Diagnosis Challenges

Diagnosing STIs is often complex. Many cases present asymptomatically, complicating timely identification. While molecular diagnostic tests are commonplace in high-income countries, low- and middle-income countries face challenges in accessibility. They often rely on syndromic management, a clinical algorithm-based approach, leading to overtreatment and missed cases, especially since a majority of STIs are asymptomatic.

Accurate diagnostic tests for STIs using molecular technology are widely used in high-income countries, especially for the diagnosis of asymptomatic infections. However, these tests are largely unavailable in low- and middle-income countries (LMICs) for chlamydia and gonorrhoea. Even where testing is available, it is often expensive and not widely accessible, impeding timely follow-up and complete care or treatment.

On the other hand, inexpensive rapid tests are available for syphilis, hepatitis B, and HIV in several resource-limited settings. Several other rapid tests are under development, holding the potential to improve STI diagnosis and treatment, especially in resource-limited settings.

Effective Treatment

Effective treatment options are currently available for several STIs. Three bacterial (chlamydia, gonorrhoea, and syphilis) and one parasitic STI (trichomoniasis) are generally curable with existing single-dose regimens of antibiotics. Antivirals manage herpes and HIV, although they cannot cure the diseases. For hepatitis B, antivirals can help fight the virus and slow damage to the liver.

However, antibiotic resistance (AMR) poses a significant threat, particularly in the case of gonorrhoea. The Gonococcal AMR Surveillance Programme (GASP) has shown high rates of resistance to many antibiotics, including quinolone, azithromycin, and extended-spectrum cephalosporins, which are last-line treatments.

AMR for other STIs like Mycoplasma genitalium, though less common, also exists. Addressing antibiotic resistance is crucial for maintaining effective treatment options.

STI Case Management

In LMICs, where resources are limited, identifying consistent and easily recognizable signs and symptoms is crucial for guiding treatment. This approach, known as syndromic management, relies on clinical algorithms and allows health workers to diagnose a specific infection based on observed syndromes (e.g., vaginal/urethral discharge, anogenital ulcers, etc.). Syndromic management is simple, assures rapid, same-day treatment, and avoids expensive or unavailable diagnostic tests for patients with symptoms.

However, this approach results in overtreatment and missed treatment opportunities since the majority of STIs are asymptomatic. Therefore, the World Health Organization (WHO) recommends countries to enhance syndromic management by gradually incorporating laboratory testing to support diagnosis. In settings where quality-assured molecular assays are available, it is recommended to treat STIs based on laboratory tests. Moreover, STI screening strategies are essential for those at higher risk of infection, such as sex workers, men who have sex with men, adolescents in some settings, and pregnant women.

To interrupt transmission and prevent re-infection, treating sexual partners is an important component of STI case management.

Controlling the Spread: Challenges and Strategies

Behavior change, a cornerstone of STI prevention, remains a complex challenge. Despite considerable efforts to identify simple interventions that can reduce risky sexual behavior, information, education, and counseling remain crucial. These interventions improve people’s ability to recognize STI symptoms, increasing the likelihood of seeking care and encouraging their sexual partners to do the same.

However, there are persistent barriers, including lack of public awareness, insufficient training among health workers, and widespread stigma around STIs. Health services for screening and treatment of STIs face challenges like limited resources, stigmatization, poor-quality services, and often out-of-pocket expenses.

Some populations with the highest rates of STIs, such as sex workers, men who have sex with men, people who inject drugs, prison inmates, mobile populations, and adolescents in high burden countries for HIV, often do not have access to adequate and friendly health services.

In many settings, STI services are often neglected and underfunded. These problems lead to difficulties in providing testing for asymptomatic infections, insufficient numbers of trained personnel, limited laboratory capacity, and inadequate supplies of appropriate medicines.

WHO Response

The World Health Organization (WHO) plays a pivotal role in addressing the STI challenge globally. Their work is guided by the Global health sector strategy on HIV, Hepatitis, and Sexually Transmitted Infections, 2022–2030. Within this framework, WHO develops global targets, norms, and standards for STI prevention, testing, and treatment.

They support the estimation and economic burden of STIs, globally monitor AMR to gonorrhoea, and lead the setting of the global research agenda on STIs, including the development of diagnostic tests, vaccines, and additional drugs for gonorrhoea and syphilis.

As part of its mission, WHO supports countries to develop national strategic plans and guidelines, create an encouraging environment allowing individuals to discuss STIs, adopt safer sexual practices, and seek treatment. They advocate for scaling up primary prevention, increasing integration of STI services within primary healthcare services, enhancing accessibility of people-centred quality STI care, facilitating adoption of point-of-care tests, and monitoring STI trends while responding to AMR in gonorrhoea.

Conclusion

In conclusion, STIs continue to be a significant global health challenge, necessitating collaborative efforts for prevention, diagnosis, and treatment. Public awareness, accessible healthcare services, ongoing research, and the addressing of behavioral and societal barriers are key to overcoming the multifaceted challenges posed by STIs.

Frequently Asked Questions (FAQs)

• Q: How common are STIs globally?

• A: STIs affect over 1 million people daily, with an estimated 374 million new infections each year.

• Q: What are the main consequences of untreated STIs?

• A: Untreated STIs can lead to HIV acquisition, adverse birth outcomes, cancers, and infertility.

• Q: What role do vaccines play in STI prevention?

• A: Vaccines for hepatitis B and HPV have been effective, with ongoing research for vaccines against other STIs.

• Q: Why is antibiotic resistance a concern in STI treatment?

• A: Antibiotic resistance, especially in gonorrhoea, is increasing rapidly, limiting treatment options.

• Q: How is WHO actively addressing the STI challenge globally?

• A: WHO sets global targets, monitors antibiotic resistance, and leads research, supporting countries in their STI prevention and treatment efforts.