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Safety Advices
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CAUTION
Caution is advised when consuming alcohol with Lucrin Depot. Please consult your doctor.
UNSAFE
Lucrin Depot is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Information regarding the use of Lucrin Depot during breastfeeding is not available. Please consult your doctor.
UNSAFE
Lucrin Depot may cause side effects which could affect your ability to drive.
Do not drive or operate machinery if you experience drowsiness, dizziness or visual disturbances whilst being treated with Lucrin Depot.
CONSULT YOUR DOCTOR
There is limited information available on the use of Lucrin Depot in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Lucrin Depot in patients with liver disease. Please consult your doctor.
Medicine Overview of Lucrin Depot 3.75mg Injection
Introduction
Lucrin Depot is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty). Lucrin Depot is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking...
... Show moreUses of Lucrin Depot
- Prostate cancer
- Endometriosis
- Uterine fibroids
- Precocious puberty (premature puberty)
Side effects of Lucrin Depot
Common
- Decreased libido
- Testicular atrophy
- Increased sweating
- Fatigue
- Muscle weakness
- Erectile dysfunction
- Bone pain
- Injection site reaction
How to use Lucrin Depot
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Lucrin Depot works
Lucrin Depot is a hormone similar to the one produced by a hypothalmus gland in the brain. It works by decreasing the blood levels of testosterone in males.
What if you forget to take Lucrin Depot?
If you miss a dose of Lucrin Depot, please consult your doctor.
Quick Tips
- Lucrin Depot helps in the treatment of locally advanced or metastatic prostate cancer.
- It may also be used to treat endometriosis and uterine fibroids.
- It is given as an injection either under the skin or into a muscle.
- It may cause dizziness and visual disturbances. Don't drive or do anything that requires mental focus until you know how it affects you.
- It will cause menstrual periods to stop. Periods will resume 7-12 weeks after the final injection. Consult your doctor if you experience menstrual bleed despite treatment.
- Use non-hormonal methods of contraception such as condoms to prevent pregnancy during treatment, as this medicine may be harmful to a developing baby.
- Long term treatment may lead to bone loss and a higher risk of bone fractures, especially if you are a heavy drinker, a smoker, or have a family history of osteoporosis.
Brief Description
Indication
Uterine fibroids, Endometriosis, Prostate cancer
Adult Dose
Advanced Prostate Cancer
Recommended Dose: 1 mg (0.2 mL) administered as a single daily SC injection.
Endometriosis
3.75 mg IM monthly for up to 6 months or 11.25 mg IM every 3 months for 2 doses (6 months total)
Recommended duration of treatment is 6 months; may treat again for additional 6 months, but with concomitant administration of norethindrone
Uterine Leiomyomata (Fibroids)
3.75 mg IM monthly for up to 3 months or 11.25 mg IM once
Use concomitant iron treatment
Child Dose
Central Precocious Puberty
Indicated when signs of sexual maturity begin to develop in girls <8 years old and boys <9 years old; may be discontinued at appropriate age of onset of puberty (eg, 11 years in females and 12 years in males), at physician's discretion
50 mcg/kg/day SC; may be titrated upward by 10 mcg/kg/day if downregulation not achieved
<2 years old: Safety and efficacy not established
Contraindication
Pregnancy, lactation; hypersensitivity to GnRH, GnRH agonist analogs or product excipients; undiagnosed abnormal vaginal bleeding.
Mode of Action
Leuprorelin is a gonadotropin-releasing hormone (GnRH) analogue. Following an initial stimulation of gonadotrophins, continuous admin of Leuprorelin leads to down regulation of GnRH receptors and subsequently reduces pituitary gonadotrophin secretion. Reduced gonadotrophin levels lead to inhibition of sex hormone (testosterone and oestrogen) production. Within 2-4 wk after treatment initiation, testosterone levels in male may be reduced to below castrate threshold.
Precaution
Vary inj site periodically. May cause transient elevation of testosterone levels during the first 1-2 wk, which may lead to worsening or onset of new symptoms (e.g. bone pain, neuropathy, haematuria) in prostate cancer patients. Ureteral obstruction and spinal cord compression have been reported; closely monitor patients with urinary obstruction and/or metastatic vertebral lesion. Leuprorelin is associated with increased risk of diabetes and certain CV diseases (heart attack, sudden cardiac death, stroke) when used in men for treatment of prostate cancer. For prostate cancer, monitor response by testosterone and prostate-specific antigen (PSA) levels. For precocious puberty in children, monitor response...
... Show moreSide Effect
>10%
Hot flashes (57%),Cardiovascular changes or ischemia (19%),Fatigue (18%),Pain (13%),Peripheral edema (12%)
1-10%
Asthenia (10%),Gynocomastia (7%),Headache (7%),Testicular atrophy (7%),Anorexia (6%),Anemia (5%),Bone pain (5%),Constipation (7%),Urinary frequency (6%),Dermatitis (5%),Dizziness (5%),Nausea and vomiting (5%),Gastroenteritis (3%),Myalgia (3%),UTI (3%),Dyspnea (2%)
Frequency Not Defined
Convulsion,Depression,Neuropathy,Decreased bone density,Hematuria,Obstruction of ureter or bladder,Impotence,Sweating,Implant site reactions (pain, bruising, edema),Spinal cord compression (rare)
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.