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Incepta Pharmaceuticals Ltd.
Generic: Paliperidone
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Safety Advices
বাংলা
English
UNSAFE
Modesto XR 6 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Modesto XR 6 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Modesto XR 6 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Modesto XR 6 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Modesto XR 6 should be used with caution in patients with kidney disease. Dose adjustment of Modesto XR 6 may be needed. Please consult your doctor.
Use of Modesto XR 6 is not recommended in patients with end-stage kidney disease.
CAUTION
Modesto XR 6 should be used with caution in patients with severe liver disease. Dose adjustment of Modesto XR 6 may be needed. Please consult your doctor.
Limited information is available on the use of Modesto XR 6 in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Modesto XR 6mg Tablet
Introduction
Modesto XR 6 is a prescription medicine used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania. Modesto XR 6 may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. It is...
... Show moreUses of Modesto XR 6
- Schizophrenia
- Mania
Side effects of Modesto XR 6
Common
- Abnormal involuntary movements
- Dizziness
- Nystagmus (involuntary eye movement)
- Sleepiness
- Tremor
How to use Modesto XR 6
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Modesto XR 6 may be taken with or without food, but it is better to take it at a fixed time.
How Modesto XR 6 works
Modesto XR 6 is an atypical antipsychotic. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts and behavior.
Quick Tips
- Take it in the morning, preferably at the same time every day.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Use caution while driving or doing anything that requires concentration as Modesto XR 6 can cause dizziness and sleepiness.
- It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy, exercise, and monitor your levels regularly.
- Monitor your blood sugar regularly as Modesto XR 6 can affect blood sugar levels.
- Do not stop taking Modesto XR 6 without talking to your doctor first as it may cause a worsening of symptoms.
Brief Description
Indication
Schizophrenia, Schizoaffective Disorder
Administration
May be taken with or without food
Adult Dose
Oral
Schizophrenia
Adult: Initially, 6 mg once daily in the morning.
May be titrated upward or downward in increments of 3 mg/day at intervals >5 days; not to exceed 12 mg/day
Schizoaffective Disorder
Indicated for schizoaffective disorder as monotherapy and as an adjunct to mood stabilizers or antidepressants
6 mg PO qDay in am (range 3-12 mg); titration may not be necessary; if exceeding 6 mg/day, increases of 3 mg/day recommended at intervals of 4 days of more; not to exceed 12 mg/day
... Show moreChild Dose
Schizophrenia
<12 years: Safety and efficacy not established
>12 years (<51 kg): 3 mg/day PO initially; may be increased if necessary in increments of 3 mg/day at intervals ?5 days; not to exceed 6 mg/day
>12 years (>51 kg): 3 mg/day PO initially; may be increased if necessary in increments of 3 mg/day at intervals ?5 days; not to exceed 12 mg/day
Schizoaffective Disorder
<18 years: Safety and efficacy not established
... Show moreRenal Dose
Renal impairment
CrCl 50-79 mL/min: 3 mg/day initially; not to exceed 6 mg/day
CrCl 10-49 mL/min: 1.5 mg/day initially; not to exceed 3 mg/day
CrCl <10 mL/min: Not recommended
... Show moreContraindication
Hypersensitivity to paliperidone or risperidone.
Mode of Action
Major metabolite of risperidone; improves negative symptoms of psychoses and reduces incidence of EPS
Has high affinity for serotonin type 2 (5-HT2) receptors; binds to dopamine D2 receptors with 20 times lower affinity than that for 5-HT2 receptors; antagonizes alpha1-adrenergic, alpha2-adrenergic, and histaminergic receptors; has moderate affinity for serotonin type 1 (5-HT1C, 5-HT1D, 5-HT1A) receptors; has weak affinity for dopamine D1 receptors; has no affinity for muscarinic, beta1-adrenergic, and beta2-adrenergic receptors
... Show morePrecaution
Patient w/ known CV disease or family history of QT prolongation, history of seizures or other conditions that potentially lower the seizure threshold, predisposition to GI obstruction, possible prolactin-dependent tumours, Parkinson's disease. Cataract surgery. Elderly w/ dementia-related psychosis and risk factors for stroke. Renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause somnolence and impairment of judgment, thinking or motor skills, if affected, avoid driving, operating machinery or performing hazardous tasks. Monitoring Parameters Monitor mental status changes, vital signs, wt, BP, electrolyte, renal and hepatic function. Closely monitor for worsening glucose control in patients w/ pre-existing DM. Lactation:...
... Show moreSide Effect
>10%
Akathisia,Somnolence,Insomnia,Parkinsonism,Tachycardia,Hyperprolactinemia,Others similar to placebo (eg, headache)
<10% (selected)
Cough,Dystonia,Extrapyramidal symptoms (EPS),Orthostatic hypotension,QT prolongation,Sialorrhea,Priapism,Weight gain,Constipation,Indigestion,Amenorrhea,Galactorrhea,Nausea,Dyspepsia,Salivation,Xerostomia,Myalgia,Extremity pain,Nasopharyngitis
... Show moreInteraction
Increased risk of QT prolongation w/ class IA (e.g. quinidine, disopyramide) and class III (e.g. amiodarone, sotalol) antiarrhythmics. Additive effects w/ drugs that cause orthostatic hypotension (e.g. other antipsychotics, tricyclics). May antagonise actions of levodopa and other dopaminergics. Additive effect w/ drugs known to lower seizure threshold (e.g. phenothiazines or butyrophenones, clozapine, tricyclics or SSRIs, tramadol, mefloquine). May reduce plasma levels w/ carbamazepine. Enhanced central effects w/ other CNS depressants. May increase plasma levels w/ valproate. May affect the absorption w/ metoclopramide.
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
Incepta Pharmaceuticals Ltd.
Generic: Paliperidone
৳ 216.00
৳ 240
10% OFF Add to Cart
Alternative Brands For Modesto XR 6
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.