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Silinor-M 1000

Name: Silinor-M 1000mg+50mg Tablet
Brand: Healthcare Pharmaceuticals Ltd.
SKU: 17490
Price: 162.5 BDT
Availability: InStock
Rating: 4.9 (3 reviews)

Tablet - (1000mg+50mg)

Healthcare Pharmaceuticals Ltd.

Generic: Metformin Hydrochloride + Sitagliptin

Safety Advices

বাংলা

English

UNSAFE

It is unsafe to consume alcohol with Silinor-M 1000.

SAFE IF PRESCRIBED

Silinor-M 1000 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

SAFE IF PRESCRIBED

Silinor-M 1000 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.

CAUTION

Silinor-M 1000 should be used with caution in patients with kidney disease. Dose adjustment of Silinor-M 1000 may be needed. Please consult your doctor. Use of Silinor-M 1000 is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

SAFE IF PRESCRIBED

Silinor-M 1000 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Silinor-M 1000 may not be needed in these patients. Please consult your doctor.

Medicine Overview of Silinor-M 1000mg+50mg Tablet

Introduction

Silinor-M 1000 is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes such as kidney damage and blindness and may reduce your chance of having a heart attack or stroke. Silinor-M 1000 can be prescribed alone or together with other diabetes medications. All diabetes medicines work best when used along with a healthy diet and regular exercise. The dose you are given will depend on your condition, blood sugar levels and what other medicines you are taking. Taking it with meals helps to reduce...

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Uses of Silinor-M 1000

Type 2 diabetes mellitus

Side effects of Silinor-M 1000

Common

Diarrhea
Nausea
Vomiting
Upset stomach
Headache
Nasal congestion (stuffy nose)
Sore throat
Respiratory tract infection
Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea

How to use Silinor-M 1000

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Silinor-M 1000 is to be taken with food.

How Silinor-M 1000 works

Silinor-M 1000 is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.

Quick Tips

Take it with food to lower your chance of having an upset stomach.

Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.

Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.

Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Janumet XR CP Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Brief Description

Indication

Type 2 DM

Administration

Should be taken with food.

Adult Dose

Oral Type 2 DM The recommended starting dose in patients not currently treated with Metformin Initially 50 mg/500 mg bd. The starting dose in patients already treated with Metformin should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and the dose of Metformin already being taken. For patients taking Metformin 850 mg twice daily, the recommended starting dose of this combination is 50 mg Sitagliptin/1000 mg Metformin hydrochloride twice daily. May adjust the dosing based on effectiveness and tolerability. Max daily dose: Sitagliptin 100 mg/metformin 2000 mg. Extended Release Tablet: Initially: Sitagliptin 50 mg or...

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Child Dose

<18 years: Safety and efficacy not established

Renal Dose

Renal impairment Obtain eGFR before starting metformin eGFR <30 mL/min/1.73 m²: Contraindicated eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment Monitor eGFR at least annually or more often for those at risk for renal impairment (eg, elderly) If eGFR falls below 45mL/min/1.73 m² while taking metformin, risks and benefits of continuing therapy should be evaluated If eGFR falls below 30 mL/min/1.73 m²: while taking metformin, discontinue the drug

Contraindication

Renal dysfunction, e.g., serum creatinine >1.5 mg/dL [males], >1.4 mg/dL [females] or abnormal creatinine clearance. Metabolic acidosis, including diabetic ketoacidosis. History of a serious hypersensitivity reaction (e.g., anaphylaxis or angioedema) to Sitagliptin + Metformin or to one of its components.

Mode of Action

Sitagliptin: Dipeptidyl peptidase 4 (DPP-4) inhibitor, thereby increasing and prolonging incretin hormone activity which are inactivated by DPP-4 enzyme. Incretins increase insulin release and synthesis from pancreatic beta cells and reduce glucagon secretion pancreatic alpha cells. Metformin: Biguanide; acts by decreasing endogenous hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization; improves glucose tolerance and lowers both basal and postprandial plasma glucose .

Precaution

Not for use in type 1 DM or treatment of ketoacidosis. Discontinue use if pancreatitis is suspected. Renal & hepatic impairment. Sulfonylurea- or insulin-induced hypoglycemia, risk of lactic acidosis, hypoxic states, surgical procedures, alcohol intake, decreased vit B12 absorption, loss of glycemic control. Pregnancy. Elderly. Childn <18 yr. Lactation: not known if crosses into breast milk, use caution Pregnancy Categories

Side Effect

1-10% Abdominal pain (2.2%),Diarrhea (2.4%),Hypoglycemia (2.1%),Nausea (1.3%),Vomiting (1.1%) Frequency Not Defined Exfoliative disorder of skin of scalp,Stevens-Johnson syndrome,Lactic acidosis (rare ),Anaphylaxis/hypersensitivity reaction,Rhabdomyolysis,Acute renal failure,Angioedema

Interaction

Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid may exacerbate loss of glycaemic control. ACE inhibitors may reduce fasting blood glucose concentrations. May increase serum level w/ cimetidine. Potentially Fatal: Concurrent use w/ iodinated contrast agents may increase the risk of metformin-induced lactic acidosis.

ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

0 People recently viewed this

Silinor-M 1000

Tablet - (1000mg+50mg)

Healthcare Pharmaceuticals Ltd.

Generic: Metformin Hydrochloride + Sitagliptin

Additional Offers

Cashback

৳100

For purchasing above ৳5000+

Cashback

৳80

For purchasing above ৳4000+

Cashback

৳60

For purchasing above ৳3000+

Cashback

৳40

For purchasing above ৳2000+

Cashback

৳20

For purchasing above ৳1000+

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

Silinor-M 1000

Medicine Overview of Silinor-M 1000mg+50mg Tablet

Silinor-M 1000

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