Intramuscular Post-exposure prophylaxis of tetanus: For adults single dose of 250 IU should be given. The dose may be increased to 500 IU in case of: 1. Infected wounds where surgically appropriate treatment cannot be achieved within 24 hours. 2. Deep or contaminated wounds with tissue damage and reduced oxygen supply, as well as foreign body injury (e.g., bites, stings or shots), 3. Burns, congelations, 4. Tissue necrosis, 5. Septicaemic abortion, 6. Adults weighing more than the average. In case of extensive burns, it is advisable to administer a second injection of 250 IU human tetanus immunoglobulin after the exsudative...
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