Application site reactions
Abnormal sensation,Pallor or blanching when the application time is very prolonged (>2 hr),Alterations in temperature sensations,Edema,Itching,Rash
Systemic reactions
Unlikely due to the small dose absorbed; may occur with repeated doses or application to large surface area
CNS excitation and/or depression
Light-headedness, nervousness, apprehension, euphoria, confusion
Dizziness,Drowsiness,Tinnitus,Blurred or double vision,Vomiting,Sensations of heat, cold or numbness,Twitching, tremors, convulsions.Unconsciousness, respiratory depression, and arrest.Cardiovascular manifestations (eg, bradycardia, hypotension, and cardiovascular collapse leading to arrest)
Potentially Fatal: Hypotension and bradycardia leading to cardiac arrest; anaphylaxis.