Pregnancy There are no available data on therapy use in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. In animal reproduction studies, econazole nitrate did not cause malformation in mice, rabbits and/or rats at oral doses 80 or 40 times the human dermal dose Animal data Econazole nitrate did not cause malformation in mice, rabbits and/or rats; fetotoxic or embryotoxic effects were observed in oral fertility studies in rats receiving 10 to 40 times the human dermal dose; similar effects were observed in embryofetal and pre- and postnatal developmental studies...