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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Victoza.
CONSULT YOUR DOCTOR
Victoza may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Victoza is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Victoza does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Victoza is safe to use in patients with kidney disease. No dose adjustment of Victoza is recommended.
However, inform your doctor if you have any underlying kidney disease.
CAUTION
Victoza should be used with caution in patients with liver disease. Dose adjustment of Victoza may be needed. Please consult your doctor.
Use of Victoza is not recommended in patients with severe liver disease.
Medicine Overview of Victoza 6mg/3ml Injection
Introduction
Victoza is a medicine used to lower blood sugar levels in adults with type 2 diabetes mellitus. This helps to prevent serious complications of diabetes like kidney damage and blindness. Proper control of diabetes also helps to lower your chances of a heart attack or a stroke. Victoza belongs to the GLP-1 (glucagon-like peptide) group of diabetes medicines. It works by helping your body produce insulin and by reducing appetite. It also helps to reduce weight in some people. This medicine should be stored in a refrigerator until you need it but do not freeze it. It is normally injected...
... Show moreUses of Victoza
- Type 2 diabetes mellitus
Side effects of Victoza
Common
- Constipation
- Decreased appetite
- Diarrhea
- Nausea
- Vomiting
- Hypoglycemia (low blood glucose level)
How to use Victoza
Your doctor or nurse will guide you how to use this medicine.
How Victoza works
Victoza is an anti-diabetic medication. It works by increasing the release of insulin from pancreas, decreases hormones that raise blood sugar levels, slows down digestion, and reduces appetite.
What if you forget to take Victoza?
If you miss a dose of Victoza, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Victoza Solution for Injection should be injected under the skin of your abdomen or thigh at the same time everyday. Do not administer intravenously or intramuscularly.
- Store the pen in the refrigerator. When refrigeration is not possible, you can also keep your pen at room temperature (less than 30°C) for up to 2 weeks. Do not freeze it.
- Victoza Solution for Injection may cause nausea. To avoid it, eat smaller meals, limit fatty food intake and stop eating when you feel full.
- Notify your doctor immediately if you have severe and/or persistent upper abdominal pain and vomiting.
Brief Description
Indication
Type 2 diabetes
Administration
It can be administered once daily at any time of day, independently of meals, and can be injected subcutaneously in the abdomen, thigh or upper arm. The injection site and timing can be changed without dose adjustment.
If dose missed, resume the once-daily regimen with the next scheduled dose; do not give an extra dose or a higher dose; if missed dose more than 3 days, initiate therapy at 0.6 mg/day to avoid GI symptoms
Adult Dose
Subcutaneous
Adjunct to Type 2 diabetes mellitus
Adult: Initially, 0.6 mg/day may increase to 1.2 mg/day after 1 wk; and a further increase to 1.8 mg/day after 1 wk if glycaemic control is not optimal.
Initial dose of 0.6 mg SC qDay is only to decrease GI adverse effects and does not provide glycemic control. When initiating , consider reducing the dose of concomitantly administered insulin secretagogues (such as sulfonylureas) to reduce the risk of hypoglycemia
Hepatic Impairment: No dosage adjustment needed.
Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal Impairment
No dosage adjustment needed.
Contraindication
Do not use in patients with a prior serious hypersensitivity reaction to any of the product components. Type 1 DM, diabetic ketoacidosis. Severe renal impairment & end-stage renal disease. Pregnancy & lactation. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)
Mode of Action
Incretin mimetic; analogue of human glucagonlike peptide-1 (GLP-1); acts as GLP-1 receptor agonist to increase insulin secretion in the presence of elevated blood glucose; delays gastric emptying to decrease postprandial glucose; also decreases glucagon secretion.
Precaution
CHF, inflammatory bowel disease, diabetic gastroparesis, preexisting thyroid disease. Increased risk of hypoglycaemia w/ sulfonylurea. Hepatic impairment. Do not administer via IV or IM. May affect ability to drive or operate machinery. Childn <18 yr. Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with liraglutide. Not for use in patients with type 1 diabetes mellitus or for treatment of diabetic ketoacidosis. Resting heart rate may increase by 2 to 3 bpm; up to 10-20 bpm increases also reported. Not a substitute for insulin. Lactation: Unknown if excreted in human milk; either discontinue...
... Show moreSide Effect
>10%
Nausea (26%),Diarrhea (17%),Vomiting (11%)
1-10%
Constipation (10%),Headache (9%),Antiliraglutide antibodies (7%),Injection-site reactions (2%)
<1% (Victoza)
Urticaria,Upper respiratory tract infection,UTI,Dizziness,Sinusitis,Nasopharyngitis,Back pain,Hypertension,Hypoglycemia (mostly in combination therapy),Pancreatitis,Papillary thyroid carcinoma,Thyroid C-cell hyperplasia
Interaction
Oral Contraceptives: Liraglutide lowered ethinyloestradiol and levonorgestrel Cmax by 12% and 13%, respectively, following administration of a single dose of an oral contraceptive product. Tmax was delayed by 1.5 hrs with liraglutide for both compounds. There was no clinically relevant effect on the overall exposure of either ethinyloestradiol or levonorgestrel. The contraceptive effect is therefore anticipated to be unaffected when co-administered with liraglutide.
Increased risk of hypoglycaemia when used w/ insulin secretagogues (e.g. sulfonylurea, meglitinide). May affect absorption of concomitantly administered oral drugs due to slow gastric emptying.
Insulin: Combination of Liraglutide with insulin has not been evaluated.
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.