Subcutaneous Diabetes Mellitus Combination rapid-onset (faster than regular insulin) and intermediate-acting insulins in fixed dose Dose regimen varies among patients depending on metabolic needs; typical daily insulin requirements range between 0.5-1 unit/kg Initially, 10 units with the largest meal of the day, dose adjustments may be made on a wkly basis according to blood glucose levels. Dose should not be increased if there is hypoglycaemic episode (<70 mg/dl) during a 3-day period.