ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

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PMB

Name: PMB 500000IU Injection
Brand: Square Pharmaceuticals PLC.
SKU: 34899
Price: 360.38 BDT
Availability: InStock
Rating: 4.9 (2 reviews)

Injection - (500000IU)

Square Pharmaceuticals PLC.

Generic: Polymyxin B Sulfate

Medicine Overview of PMB 500000IU Injection

বাংলা

English

Indication

Susceptible infections, Meningitis

Administration

IV/IM/IT Preparation IV: dilute 500,000 U in 300-500 mL D5W IM: reconstitute vial with 2 mL SWI , NS, or procaine HCl 1% solution Intrathecal (IT): reconstitute vial with10 mL NS; DO NOT use procaine HCl for IT IV/IM Administration IV: infuse over 60-90 min IM: give deep into upper outer quadrant of gluteal muscles

Adult Dose

Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max: 2,000,000 U/day. Intramuscular Susceptible infections Adult: 25,000-30,000 U/kg daily in divided doses 4-6 hrly. Max: 2,000,000 U/day. Intrathecal Meningitis Adult: 50,000 U once daily for 3-4 days, then on alternate days for at least 2 wk after CSF cultures are negative and CSF glucose content is normal. Max: 2,000,000 U/day.

Child Dose

Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max: 2,000,000 U/day. Child: 2 yr Same as adult dose but not routinely recommended due to pain at injection sites. Intrathecal Meningitis Child: 2 yr Same as adult dose.

Renal Dose

Renal Impairment CrCl >20 mL/minute: give 75-100% usual dose/day divided q12hr CrCl 5-20 mL/minute: give 50% usual dose/day divided q12hr CrCl <5 mL/minute: give 15% usual dose/day q12hr

Contraindication

Hypersensitivity to polymyxins; Concurrent use w/ nephrotoxic and/or neurotoxic drugs and neuromuscular blockers.

Mode of Action

Polymyxin B binds to phospholipids, alters permeability and disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids.

Precaution

Oliguria, myasthenia gravis, pregnancy, renal disease Potential risk of nephrotoxicity and neurotoxicity May inhibit neuromuscular transmission Inactivated by strong acidic or alkaline solution Discontinue if diminished urine output, rise in SCr or BUN, or signs of respiratory paralysis appear Do not use IM routinely, particularly in peds, because of severe inj site pain

Side Effect

Frequency Not Defined Anaphylactoid reactions with dyspnea and tachycardia Eosinophilia Fever Nephrotoxicity Neurotoxicity Skin exanthemata Urticaria

Pregnancy Category Note

Pregnancy Category: B: use when benefits outweigh risks Lactation: use caution; no data

Interaction

Potentially Fatal: Additive neurotoxic or nephrotoxic effect w/ bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, colistin. Increased risk of resp paralysis w/ neuromuscular blockers (e.g. anaesthetics, muscle relaxants).

ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

0 People recently viewed this

PMB

Injection - (500000IU)

Square Pharmaceuticals PLC.

Generic: Polymyxin B Sulfate

Additional Offers

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৳100

For purchasing above ৳5000+

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৳80

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৳60

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৳40

For purchasing above ৳2000+

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৳20

For purchasing above ৳1000+

Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.