Palopag 400

Name: Palopag 400mg Tablet
Brand: Incepta Pharmaceuticals Ltd.
SKU: 36553
Price: 72 BDT
Availability: InStock
Rating: 4.9 (1 reviews)

Tablet - (400mg)

Incepta Pharmaceuticals Ltd.

Generic: Selexipag

Out of Stock

Currently unavailable, please request or choose another variant.

৳ 72.00
৳ 80
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Medicine Overview of Palopag 400mg Tablet

বাংলা

English

Indication

Pulmonary Arterial Hypertension

Administration

Swallow tablet whole; do not split, crush, or chew Tolerability may be improved when taken with food Dose interruptions and discontinuations If a dose is missed, patients should take a missed dose as soon as possible unless the next dose is within the next 6 hr If treatment is missed for ?3 days, restart selexipag at a lower dose and then titrate to desired effect and tolerance

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Adult Dose

Pulmonary Arterial Hypertension Indicated for pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH Starting dose: 200 mcg PO BID Increase dose by increments of 200 mcg BID, usually at weekly intervals, to the highest tolerated dose; not to exceed 1600 mcg BID Hepatic impairment Mild (Child-Pugh A): No dosage adjustment required Moderate (Child-Pugh B): Starting dose is 200 mcg qDay; increase by increments of 200 mcg/day at weekly intervals, as tolerated Severe (Child-Pugh C): Avoid use

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Renal Dose

Renal impairment: No dosage adjustment required

Contraindication

Concomitant use of strong CYP2C8 inhibitors (eg, gemfibrozil)

Mode of Action

Selectively activates the prostacyclin receptor (ie, IP-receptor), one of 5 types of prostanoid receptors Unlike prostacyclin analogs, selexipag is selective for the IP receptor over other prostanoid receptors (ie, EP1-4, DP, FP, TP) Activating the IP receptor induces vasodilation and inhibits proliferation of vascular smooth muscle cells

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Precaution

If signs of pulmonary edema occur, consider the possibility of associated pulmonary veno-occlusive disease (PVOD); if PVOD is confirmed, discontinue selexipag Lactation Unknown if distributed in human breast milk Selexipag or its metabolites were present in the milk of rats

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Side Effect

>10% Headache (65%) Diarrhea (42%) Jaw pain (26%) Nausea (33%) Vomiting (18%) Pain in extremity (17%) Myalgia (16%) Flushing (12%) Arthralgia (11%) Rash (11%) 1-10% Hemoglobin decreased below 10 g/dL (8.6%) Anemia (8%) Decreased appetite (6%) Frequency Not Defined TSH reduced (up to −0.3 MU/L from a baseline of 2.5 MU/L) Symptomatic hypotension

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Interaction

Coadministration with strong CYP2C8 inhibitors may result in a significant increase in exposure to selexipag and its active metabolite Avoid concomitant administration with strong inhibitors of CYP2C8 Concomitant administration with an inducer of CYP2C8 and UGT 1A3 and 2B7 enzymes (rifampin) halved exposure to active metabolite; increase dose up to twice of the normal dose when co-administered with rifampin; reduce therapy dose when rifampin is stopped

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Palopag 400

Tablet - (400mg)

Incepta Pharmaceuticals Ltd.

Generic: Selexipag

Out of Stock

Currently unavailable, please request or choose another variant.

৳ 72.00
৳ 80
10% OFF

Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.