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ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

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Dacocent

Name: Dacocent 45mg Tablet
Brand: Incepta Pharmaceuticals Ltd.
SKU: 39518
Price: 2850 BDT
Availability: InStock
Rating: 4.9 (1 reviews)

Tablet - (45mg)

Incepta Pharmaceuticals Ltd.

Generic: Dacomitinib

Medicine Overview of Dacocent 45mg Tablet

বাংলা

English

Indication

Non-small Cell Lung Cancer

Administration

Administer with or without food at the same time each day

Adult Dose

Non-small Cell Lung Cancer Indicated for first-line treatment of patients with metastatic non-small lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test 45 mg PO qDay Continue until disease progression or unacceptable toxicity occurs Hepatic impairment Mild or moderate (total bilirubin ?3x upper limit of normal [ULN] and any AST): No dosage adjustment necessary Severe (total bilirubin 3-10x ULN and any AST): Recommended dose not established

Renal Dose

Renal impairment Mild or moderate (CrCl 30-89 mL/min estimated by Cockcroft-Gault equation): No dosage adjustment necessary Severe (CrCl <30 mL/min): Recommended dose not established

Mode of Action

Irreversible kinase inhibitor of the human EGFR family (EGFR/HER1, HER2, and HER4) and certain EGFR-activating mutations (exon 19 deletion or the exon 21 L858R substitution mutation) Also inhibited the activity of DDR1, EPHA6, LCK, DDR2, and MNK1 in vitro at clinically relevant concentrations Demonstrates dose-dependent inhibition of EGFR and HER2 autophosphorylation and tumor growth in mice bearing SC implanted human tumor xenografts driven by HER family targets including mutated EGFR; also, exhibits antitumor activity in orally dosed mice bearing intracranial human tumor xenografts driven by EGFR amplifications

Precaution

Severe and fatal ILD/pneumonitis occurred; monitor for pulmonary symptoms indicative of ILD/pneumonitis; withhold treatment and promptly investigate for ILD in patients who present with worsening of respiratory symptoms, which may be indicative of ILD (eg, dyspnea, cough, fever); permanently discontinue treatment if ILD is confirmed Severe and fatal diarrhea occurred; promptly initiate antidiarrheal treatment (loperamide or diphenoxylate hydrochloride with atropine sulfate) for diarrhea

Side Effect

>10% (All Grades) Diarrhea (87%) Rash (69%) Paronychia (64%) Stomatitis (45%) Anemia (44%) Hypoalbuminemia (44%) Lymphopenia (42%) Increased ALT (40%) Hyperglycemia (36%) Increased AST (35%) Hypocalcemia (33%) Decreased appetite (31%) Dry skin (30%) Hypokalemia (29%) Decreased weight (26%) Hyponatremia (26%) Increased creatinine (24%) Alopecia (23%) Increased alkaline phosphatase (22%) Hypomagnesemia (22%) Pruritus (21%) Cough (21%) Nasal mucosal disorder (19%) Conjunctivitis (19%) Nausea (19%) Hyperbilirubinemia (16%) Palmar-plantar erythrodysesthesia syndrome (15%) Pain in extremity (14%) Dyspnea (13%) Constipation (13%) Asthenia (13%) Mouth ulceration (12%) Musculoskeletal pain (12%) Upper respiratory tract infection (12%) Dermatitis (11%) Insomnia (11%)

Pregnancy Category Note

Pregnancy Based on findings from animal studies and its mechanism of action, fetal harm may occur when administered to a pregnant woman There are no available data on use in pregnant women Verify pregnancy status of females of reproductive potential prior to initiating treatment Advise females of reproductive potential to use effective contraception during treatment and for at least 17 days after final dose Animal data In animal reproduction studies, oral administration of dacomitinib to pregnant rats during organogenesis period resulted in an increased incidence of postimplantation loss and reduced fetal body weight at doses resulting in similar exposures seen...

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ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

0 People recently viewed this

Dacocent

Tablet - (45mg)

Incepta Pharmaceuticals Ltd.

Generic: Dacomitinib

Additional Offers

Cashback

৳100

For purchasing above ৳5000+

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৳80

For purchasing above ৳4000+

Cashback

৳60

For purchasing above ৳3000+

Cashback

৳40

For purchasing above ৳2000+

Cashback

৳20

For purchasing above ৳1000+

Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

Dacocent

Medicine Overview of Dacocent 45mg Tablet

Dacocent

Alternative Brands For Dacocent