Women with undiagnosed abnormal uterine bleeding, known, suspected, or past history of breast cancer, known or suspected estrogen-dependent neoplasia, active deep venous thrombosis, pulmonary embolism, or history of these conditions, active arterial thromboembolic disease, hypersensitivity (e.g., anaphylaxis, angioedema) to estrogens, bazedoxifene, or any ingredients, known hepatic impairment, or other known thrombophilic disorders are all contraindications.