Susceptible infections, Keratitis, Allergic conjunctivitis, Blepharitis, Allergic and inflammatory conditions of the eye, Chronic conjunctivitis, Spring catarrh,
Adult Dose
Ophthalmic
Superficial ophth infections:
Instill 1-2 drops 4 hrly, up to 2 drops hrly in severe cases.
As eye oint: Apply 1/2 inch into the conjunctival sac 2-3 times daily.
Contraindication
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment.
Mode of Action
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
Hydrocortisone is a corticosteroid used for its anti-inflammat...
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Precaution
Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses,...
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