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Kolchin 0.6
Incepta Pharmaceuticals Ltd.
Generic: Colchicine
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Kolchin 0.6. Please consult your doctor.
CONSULT YOUR DOCTOR
Kolchin 0.6 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Kolchin 0.6 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Kolchin 0.6 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Kolchin 0.6 should be used with caution in patients with kidney disease. Dose adjustment of Kolchin 0.6 may be needed. Please consult your doctor.
Use of Kolchin 0.6 should preferably be avoided if you have serious kidney disease.
CAUTION
Kolchin 0.6 should be used with caution in patients with severe liver disease. Dose adjustment of Kolchin 0.6 may be needed. Please consult your doctor.
However, close monitoring is recommended for patients with mild to moderate liver disease also but dose adjustment is not necessary.
Medicine Overview of Kolchin 0.6 0.6mg Tablet
Introduction
Kolchin 0.6 is a medicine used in the treatment and prevention of gout. It reduces inflammation which causes pain, swelling, and other symptoms of gout. Kolchin 0.6 can be taken with or without food. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. If you stop, your symptoms may get worse. Some common side effects of this medicine are nausea, vomiting, abdominal pain, and diarrhea. Talk to your doctor if any of these...
... Show moreUses of Kolchin 0.6
- Gout
Side effects of Kolchin 0.6
Common
- Nausea
- Vomiting
- Abdominal pain
How to use Kolchin 0.6
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kolchin 0.6 may be taken with or without food, but it is better to take it at a fixed time.
How Kolchin 0.6 works
Kolchin 0.6 reduces inflammation which causes pain, swelling and other symptoms of gout.
What if you forget to take Kolchin 0.6?
If you miss a dose of Kolchin 0.6, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Kolchin 0.6 is used for the treatment and prevention of gout.
- It interacts with many different medicines. Inform your doctor about all the medications that you are taking.
- Inform your doctor if you have serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toe.
- It can lower your body's ability to make new blood cells. Inform your doctor know if you have frequent bleeding, bruising, fevers, or if you are always tired.
- Do not take Kolchin 0.6 if you have severe liver disease, kidney disease, or if you are pregnant or breastfeeding.
Brief Description
Indication
Acute gout, Familial Mediterranean Fever, Behcet's disease, Gouty arthritis
Administration
Should be taken with food.
Adult Dose
Gout Treatment of acute gout flares (Colcrys): 1.2 mg PO at first sign of flare, then 0.6 mg 1 hr later; not to exceed 1.8 mg in 1-hr period Prophylaxis (Colcrys, Mitigare): 0.6 mg PO once daily or q12hr; not to exceed 1.2 mg/day; after gout flare, wait 12 hr to continue prophylaxis Familial Mediterranean Fever Colcrys: 1.2-2.4 mg/day PO in single daily dose or divided q12hr; increased in 0.3 mg/day increments as necessary to control disease; decreased in 0.3 mg/day increments if intolerable side effects develop; not to exceed 2.4 mg/day Hepatic impairment (gout) Mild to moderate: Dosage adjustment...
... Show moreChild Dose
Gout
16 years
Treatment of acute gout flares: 1.2 mg PO at first sign of flare, then 0.6 mg 1 hr later; not to exceed 1.8 mg in 1-hr period
Prophylaxis: 0.6 mg PO once daily or q12hr; not to exceed 1.2 mg/day; after gout flare, wait 12 hr to continue prophylaxis
Familial Mediterranean Fever
12 years: 1.2-2.4 mg/day PO in single daily dose or divided q12hr
Renal Dose
Renal impairment (gout) Mild (CrCl 50-80 mL/min) and moderate (CrCl 30-50 mL/min): Dosage adjustment not necessary; monitor patients for adverse effects Severe (CrCl <30 mL/min): Dosage adjustment not necessary; do not repeat more frequently than every 2 weeks Hemodialysis: 0.6 mg once; do not repeat more frequently than every 2 weeks Renal impairment (familial Mediterranean fever) Mild (CrCl 50-80 mL/min) and moderate (CrCl 30-50 mL/min): Monitor patients for adverse effects; dosage adjustment may be required Severe (CrCl <30 mL/min): 0.3 mg/day initially; dosage increases should be done with adequate monitoring for adverse effects Hemodialysis: 0.3 mg PO once; dosage increases...
... Show moreContraindication
Hypersensitivity; blood dyscrasias, severe renal impairment, pregnancy, debilitated patients; SC/IM admin.
Mode of Action
Colchicine, a phenanthrene derivative, exerts its effect by reducing the inflammatory response to the deposited urate crystals and also by diminishing phagocytosis in joints. It inhibits lactic acid production by leucocytes, thereby interrupting urate deposition and inflammatory response that sustains the acute gout attack.
Precaution
Elderly; GI disease. Cardiac, renal and hepatic impairment; prolonged therapy not recommended; lactation.
Lactation: Drug enters breast milk; use with caution (American Academy of Pediatrics Committee states that drug is "compatible" with nursing)
Side Effect
>10%
Gastrointestinal (GI) effects (eg, diarrhea, nausea, cramping, abdominal pain, vomiting) (26-77%)
1-10%
Fatigue (1-4%),Gout (0-4%),Pharyngolaryngeal pain (2-3%),Headache (1-2%)
Pregnancy Category Note
Pregnancy Available human data from published literature on colchicine use in pregnancy over several decades have not identified any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes Lactation Colchicine is present in human milk No adverse events in breastfed infants in the published literature after administration of colchicine to lactating women No data available on the effects of colchicine on milk production Consider developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal...
... Show moreInteraction
Reversible malabsorption of vitamin B12 may occur because of ileal mucosal function alteration. Response to CNS depressants and sympathomimetics may increase when used concurrently with colchicine. Increased risk of myopathy when used concurrently with simvastatin.
Potentially Fatal: With ciclosporin, increased risk of nephrotoxicity and myotoxicity. Risk of colchicine toxicity when used with macrolides.
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