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Safety Advices
বাংলা
English
UNSAFE
Loperin may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Loperin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Loperin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Loperin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Loperin is safe to use in patients with kidney disease. No dose adjustment of Loperin is recommended.
However, inform your doctor if you have any underlying kidney disease.
CAUTION
Loperin should be used with caution in patients with liver disease. Dose adjustment of Loperin may be needed. Please consult your doctor.
Medicine Overview of Loperin 2mg Capsule
Introduction
Loperin is used in the treatment of diarrhea. It should not be used in patients with dysentery (diarrhea with blood). Loperin is taken with or without food in a dose and duration as advised by the doctor. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are headache, nausea, and constipation. Most of these...
... Show moreUses of Loperin
- Diarrhea
Side effects of Loperin
Common
- Constipation
- Nausea
- Headache
- Stomach pain
How to use Loperin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Loperin may be taken with or without food, but it is better to take it at a fixed time.
How Loperin works
Loperin is an anti-diarrhoeal medication. It works by slowing down the contraction of the intestines thereby decreasing the speed at which the contents pass through it. This allows more time for reabsorption of fluids and nutrients, making the stools more solid and less frequent.
Quick Tips
- You have been prescribed Loperin for the treatment of diarrhea.
- Diarrhea can cause water loss and electrolyte imbalance. Drink plenty of fluids to help keep you hydrated.
- Consult your doctor if your diarrhea lasts for more than 48 hours.
- Do not use Loperin if you have blood in your stool or if you are severely constipated.
- Use caution while driving or doing anything that requires concentration as Loperin can cause dizziness and sleepiness.
- Stop taking the medication as soon as your symptoms are relieved.
Brief Description
Indication
Diarrhea
Administration
May be taken with or without food.
Adult Dose
Acute Diarrhea
4 mg initially, then 2 mg after each loose stool; not to exceed 16 mg/day (8 mg/day for self-medication); discontinue if no improvement seen within 48 hours
Chronic Diarrhea
4 mg initially, then 2 mg after each loose stool until controlled, and then 4-8 mg/day in divided doses
Traveler's Diarrhea
4 mg after first loose stool, then 2 mg after each subsequent stool; not to exceed 8 mg/day
Child Dose
Acute Diarrhea
First Day of Treatment
2-6 years (13-20 kg): 1 mg q8hr PO
6-8 years: (20-30 kg): 2 mg q12hr PO
8-12 years (>30 kg): 2 mg q8hr PO
Second & Subsequent Doses
0.1 mg/kg PO after each loose stool; not to exceed dose recommended for first 24 hours
Chronic Diarrhea
0.08-0.24 mg/kg/day PO divided q12hr
Traveler's Diarrhea
12 years: 4 mg after first loose stool, then 2 mg after each subsequent stool; not to exceed 8 mg/day
Contraindication
Conditions when inhibition of peristalsis is undesirable (e.g. ileus or megacolon); antibiotic induced colitis; active inflammatory bowel disease; if abdominal distention develops during use; abdominal pain in the absence of diarrhoea.
Mode of Action
Loperamide inhibits peristalsis and prolongs transit time by acting directly on intestinal wall muscles. It also reduces faecal volume, increases viscosity and decreases fluid and electrolyte loss.. Slows intestinal motility through opioid receptor; has direct effects on circular and longitudinal muscle;.
Precaution
Concomitant specific therapy must be given in those with infectious diarrhoea; hepatic dysfunction; infants; pregnancy, lactation.
Lactation: Not known if distributed in breast milk; use caution
Side Effect
Abdominal pain, distention, and discomfort; paralytic ileus; constipation, dry mouth, drowsiness, dizziness, fatigue, rash.
Potentially Fatal: Toxic megacolon.
Interaction
Bioavailability increased by co-trimoxazole, ritonavir, saquinavir. Respiratory depression reported when administered with quinidine. Loperamide increases GI absorption of desmopressin and decreases exposure to saquinavir.
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