It is not known whether it is safe to consume alcohol with Megatrim. Please consult your doctor.
CONSULT YOUR DOCTOR
Megatrim is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Megatrim is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
There may be a possibility of skin rash in the baby.
CONSULT YOUR DOCTOR
It is not known whether Megatrim alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Megatrim should be used with caution in patients with kidney disease. Dose adjustment of Megatrim may be needed. Please consult your doctor.
Use of Megatrim is not recommended in patients with severe kidney disease.
CAUTION
Megatrim should be used with caution in patients with liver disease. Dose adjustment of Megatrim may be needed. Please consult your doctor.
Use of Megatrim is not recommended in patients with the severe liver disease.
Medicine Overview of Megatrim 800mg+160mg Tablet
Introduction
Megatrim is a combination medicine that is used to treat various types of bacterial infections such as pneumonia, bronchitis, infections of urinary tract, ear, and abdomen. It prevents the growth of microorganisms to cure the infection.
Megatrim is ... Show more
Uses of Megatrim
Bacterial infections
Side effects of Megatrim
Common
Nausea
Vomiting
Skin rash
Allergic reaction
How to use Megatrim
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Megatrim is to be taken with food.
How Megatrim works
Megatrim is a combination of two antibiotics: Sulfamethoxazole and Trimethoprim. These antibiotics work by preventing the bacteria from producing folic acid, a nutrient required for bacterial multiplication. Together, they treat your infection effect ... Show more
Quick Tips
You have been prescribed Megatrim for the treatment of many types of bacterial infections.
Finish the prescribed course of Megatrim, even if you start to feel better. Stopping it early may make the infection come back and harder to ... Show more
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find bloo ... Show more
Stop taking Megatrim and inform your doctor if you develop skin rash/blisters or other unexplained skin reaction while taking Megatrim.
In case of long-term use, have regular monthly blood tests to monitor your blood cells as suggested by your doctor.
Brief Description
Indication
Upper and lower respiratory tract infections, Gastrointestinal tract infections, Renal and urinary tract infections, Skin and wound infections, Septic ... Show more
Adult Dose
Oral
Acute exacerbations of chronic bronchitis ; Acute otitis media; Urinary tract infections, GI infections; Resp and urinary tract infections; Susc ... Show more
Child Dose
Child:
Oral
8–10 mg TMP/kg/day q12h
2 mg TMP/kg/day for UTI prophylaxis q24h
15–20 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumoni ... Show more
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<15 Not recommended.
15-30 Half the standard dose.
Contraindication
Known hypersensitivity to trimethoprim or sulfonamides; severe hepatic failure or marked liver parenchymal damage, jaundice; serious haematological di ... Show more
Mode of Action
Co-trimoxazole exhibits the synergistic actions of its components (sulfamethoxazole and trimethoprim) by 10-fold. Sulfamethoxazole inhibits dihydrofol ... Show more
Precaution
Patient w/ severe allergy, bronchial asthma, thyroid dysfunction. Renal and mild to moderate hepatic impairment. Lactation. Patient Counselling May im ... Show more
Side Effect
Allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like synd ... Show more
Interaction
Reduced ciclosporin concentrations in blood when used concurrently. Increases toxicity of methotrexate. Inhibits phenytoin clearance. Potentiates warf ... Show more
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.