Caution is advised when consuming alcohol with Methox 10. Please consult your doctor.
UNSAFE
Methox 10 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Methox 10 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Methox 10 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Methox 10 should be used with caution in patients with kidney disease. Dose adjustment of Methox 10 may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
CAUTION
Methox 10 should be used with caution in patients with liver disease. Dose adjustment of Methox 10 may be needed. Please consult your doctor.
Use of Methox 10 is not recommended in patients with severe liver disease.
Medicine Overview of Methox 10mg Tablet
Introduction
Methox 10 is a medicine used to treat rheumatoid arthritis where it can prevent further joint damage. It is also used to treat severe forms of a skin disease called psoriasis by killing cells in the skin which are growing too quickly.
Methox 10 may ... Show more
Uses of Methox 10
Rheumatoid arthritis
Psoriasis
Side effects of Methox 10
Common
Abdominal pain
Indigestion
Loss of appetite
Nausea
Vomiting
Tiredness
Mouth sore
How to use Methox 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Methox 10 may be taken with or without food, but it is better to take it at a fixed time.
How Methox 10 works
Methox 10 is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid ... Show more
Quick Tips
Take it once a week, on the same day every week.
Drink plenty of liquids to stay hydrated while taking this medication.
Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
It may take 6 to 8 weeks for Methox 10 to work. Keep taking the medication as prescribed.
Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Brief Description
Indication
Burkitt's lymphoma, Choriocarcinoma, Mycosis fungoides, Crohn's disease, Psoriasis, Osteosarcoma, Breast cancer, lymphosarcoma, Acute lymphoblastic le ... Show more
Administration
Should be taken on an empty stomach. Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort. Avoid taking w/ milk-rich products ... Show more
Adult Dose
Adult:
PO
Burkitt's lymphoma 10-25 mg/day for 4-8 days, repeat after 7-10 days.
Choriocarcinoma 15-30 mg/day for 5 days, repeat after an interva ... Show more
Child Dose
Polyarticular Juvenile Idiopathic Arthritis
Initial: 10 mg/m² PO/IM/SC qWeek
Meningeal Leukemia
<1 year: 6 mg intrathecally (IT) every 2-5 days
... Show more
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
61-80 75% of dose
51-60 70% of dose
10-50 30-50% of dose
<10 Avoid use
Intermittent hemo ... Show more
Contraindication
Severe renal or hepatic impairment, pre-existing profound bone marrow suppression in patients with psoriasis or rheumatoid arthritis, alcoholic liver ... Show more
Mode of Action
Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of red ... Show more
Precaution
Hepatic or renal impairment, bone marrow depression, elderly, neonates. Ulcerative disorders of the GI tract. Monitor haematological, renal and hepati ... Show more
Side Effect
>10%
Arachnoiditis with intrathecal administration,Subacute toxicity with intrathecal administration (paralysis of extremities, cranial nerve palsy, ... Show more
Interaction
Decreased effectiveness with folic acid and its derivatives.
Potentially Fatal: Increased toxicity with NSAIDs and salicylates; probenecid; some pe ... Show more
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.