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Norbit
Incepta Pharmaceuticals Ltd.
Generic: Disopyramide
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Norbit. Please consult your doctor.
CONSULT YOUR DOCTOR
Norbit may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Norbit is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Norbit may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Norbit should be used with caution in patients with kidney disease. Dose adjustment of Norbit may be needed. Please consult your doctor.
CAUTION
Norbit should be used with caution in patients with liver disease. Dose adjustment of Norbit may be needed. Please consult your doctor.
Medicine Overview of Norbit 100mg Capsule
Introduction
Norbit is a medicine used to treat arrhythmia (abnormal heart rhythm). It restores normal heart rhythm by blocking abnormal electrical signals in the heart. This helps to maintain a regular and steady heartbeat. Norbit should be taken regularly as advised by the doctor. You may take it without food but it is better to take this medicine at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. Side effects like constipation, dryness in mouth, urinary retention and blurred...
... Show moreUses of Norbit
- Arrhythmia
Side effects of Norbit
Common
- Blurred vision
- Worsening of pre-existing glaucoma
- Constipation
- Dryness in mouth
- Urinary retention
How to use Norbit
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Norbit is to be taken empty stomach.
How Norbit works
Norbit is an anti-arrhythmic medication. It works by blocking abnormal electrical signals in the heart to correct irregular heartbeat to a normal rhythm.
What if you forget to take Norbit?
If you miss a dose of Norbit, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- It may cause dizziness. Do not drive or perform activities require mental focus until you know how it affects you.
- Do not start any medicine including prescription or over-the-counter medicines without informing your doctor, as they may alter Norbit levels in your body.
- Your doctor may get blood tests done to check your sodium and potassium levels, kidney function, and lung function before starting treatment with this medicine.
- Your doctor may regularly monitor blood sugar level while taking this medicine.
- Inform your doctor if you experience slow or fast heart rate, chest pain, shortness of breath.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
- Do not stop taking medication suddenly without talking to your doctor.
Brief Description
Indication
Ventricular tachycardia, Supraventricular arrhythmias,Ventricular arrhythmias
Adult Dose
Oral
Supraventricular and ventricular arrhythmias
Adult: 300-800 mg daily in divided doses (as conventional capsules every 6 hr), adjusted according to patient's response.
Hepatic impairment: 400 mg daily in divided doses. Liver cirrhosis: consider a therapeutic range 50% lower than in patients with normal hepatic function.
Child Dose
Oral
Ventricular Arrhythmias
<1 year old: 10-30 mg/kg/day divided q6hr PO
1-4 years old: 10-20 mg/kg/day divided q6hr PO
4-12 years old: 10-15 mg/kg/day divided q6hr PO
12-18 years old: 6-15 mg/kg/day divided q6hr PO
Renal Dose
Renal impairment:
CrCl (ml/min)
>40 400 mg daily in divided doses.
30-40 100 mg every 8 hr; avoid modified release preparations.
15-30 100 mg every 12 hr; avoid modified release preparations.
<15 100 mg every 24 hr; avoid modified release preparations.
Contraindication
Patients with complete heart block; glaucoma; predisposition to urinary retention; myasthenia gravis. Sinus node disease in absence of pacemaker. Cardiomyopathy. Cardiogenic shock. Hypotension. Hypersensitivity. Children.
Mode of Action
Disopyramide is a Ia antiarrhythmic agent which acts by decreasing myocardial excitability and conduction velocity. It lengthens the effective refractory period of the atrium. It also possesses antimuscarinic and negative inotropic effects.
Precaution
Conduction disorders or uncompensated heart failure. Pregnancy and lactation. Renal and hepatic failure. Family history of glaucoma. Correct potassium deficiency.
Lactation: crosses into breast milk, discontinue drug or do not nurse
Side Effect
>10%
Xerostomia (32%),Urinary hesitancy (23%),Constipation (11%)
1-10%
Impotence,Urinary urgency,Urinary retention,Dry throat,Weight gain,Abdominal distension,Flatulence,Anorexia,Vomiting,Nausea,Dermatoses,Pruritus,Generalized rash,Increased triglycerides and cholesterol,Hypokalemia,Muscle weakness,Muscular pain,Dyspnea,Blurred vision,Dry eyes,Fatigue,Malaise,Headache,Dizziness,Nervousness,Syncope,Hypotension,Chest pain,Edema
<1%
AV block,Hypoglycemia (rare),Agranulocytosis,Respiratory distress,Creatinine increased,Psychotic reaction,Paresthesia,Lupus (rare),Peripheral neuropathy,Insomnia
Potentially Fatal: Urinary retention, severe cardiovascular depression if given as rapid IV inj. High risk of recurrence of failure in patients with history of congestive cardiac failure. Negative inotropic effect especially prominent in patients with cardiomyopathy, hypertension and uncompensated cardiac failure.
Interaction
Avoid other Class I antiarrhythmics and other cardiac depressants including beta-blockers except in life-threatening arrhythmias. Risk of worsening of arrhythmias, precipitation of new arrhythmias and ventricular fibrillation when used with other anti-arrhythmics. Reduced efficacy when co-admin with phenytoin.
Potentially Fatal: Enhanced antimuscarinic effects with other antimuscarinic drugs. Potentiates negative chronotropic and inotropic effects of ?-blockers and verapamil. Potentiates inhibitory effect on the conduction system produced by digitalis. Potentiates QT interval prolongation produced by TCAs and amiodarone.
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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