It is not known whether it is safe to consume alcohol with Palbocent 125. Please consult your doctor.
CONSULT YOUR DOCTOR
Palbocent 125 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Palbocent 125 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Palbocent 125 may cause side effects which could affect your ability to drive.
It may cause fatigue in some people. If this happens, you should exercise caution when driving or using machines.
SAFE IF PRESCRIBED
Palbocent 125 is safe to use in patients with kidney disease. No dose adjustment of Palbocent 125 is recommended.
CAUTION
Palbocent 125 should be used with caution in patients with liver disease. Dose adjustment of Palbocent 125 may be needed. Please consult your doctor.
Medicine Overview of Palbocent 125mg Capsule
Introduction
Palbocent 125 is used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. It is given together with hormonal anticancer therapies.
P ... Show more
Uses of Palbocent 125
Breast cancer
Side effects of Palbocent 125
Common
Fatigue
Hair loss
Rash
Vomiting
Diarrhea
Nausea
Decreased blood cells (red cells, white cells, and platelets)
Infection
Decreased appetite
Fever
How to use Palbocent 125
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Palbocent 125 is to be taken with food.
How Palbocent 125 works
Palbocent 125 is an anti-cancer medication. Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus a ... Show more
Quick Tips
Take it with food, preferably at the same time every day.
If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed ... Show more
Use effective contraception method to prevent pregnancy while taking this medicine.
It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, ch ... Show more
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Do not stop taking the medication without talking to your doctor first.
Brief Description
Indication
Indicated for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, advanced breast cancer, in combination with an ... Show more
Administration
Hard Capsule: Should be taken with food. Take at the same time each day. Swallow whole, do not chew/crush/open. Avoid grapefruit products.
Adult Dose
Oral
Hormone receptor positive, HER2-negative locally advanced carcinoma of breast, Hormone receptor positive, HER2-negative metastatic carcinoma of ... Show more
Renal Dose
Renal impairment
Mild, moderate, or severe (CrCl >15 mL/min): No dose adjustment required
Hemodialysis: Not studied
Contraindication
Pregnancy and lactation.
Mode of Action
Palbociclib is a reversible, selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6. Cyclin D1, CDK 4 and 6 are downstream of multiple signallin ... Show more
Precaution
Neutropenia observed in clinical trials; febrile neutropenia also reported; monitor CBC count prior to starting drug and at the beginning of each cycl ... Show more
Side Effect
>10%
Neutropenia, all grades (75%)
Neutropenia, grade 3 (48%)
Leukopenia, all grades (43%)
Fatigue, all grades (41%)
Anemia, all grades (35%)
Up ... Show more
Interaction
Increased plasma concentration and systemic exposure with strong CYP3A inhibitors (e.g. clarithromycin, telithromycin, itraconazole, ketoconazole, pos ... Show more
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.