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Perpen
Rangs Pharmaceuticals Ltd.
Generic: Flucloxacillin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Perpen. Please consult your doctor.
SAFE IF PRESCRIBED
Perpen is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CAUTION
Perpen should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
SAFE
Perpen does not usually affect your ability to drive.
Medicine Overview of Perpen 250mg Capsule
Introduction
Perpen is an antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, skin and soft tissue, bones and joints and blood. Perpen is a penicillin-type of antibiotic, which mainly fights and stops the growth of the gram-positive type of bacteria. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. This medicine should be used regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip...
... Show moreUses of Perpen
- Bacterial infections
Side effects of Perpen
Common
- Nausea
- Vomiting
- Diarrhea
- Allergic reaction
- Injection site reactions (pain, swelling, redness)
How to use Perpen
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it.
How Perpen works
Perpen is an antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is needed for them to survive.
What if you forget to take Perpen?
If you miss a dose of Perpen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Perpen for the treatment of bacterial infections.
- It is given by an injection into a vein or muscle, or via a drip into a vein.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
Brief Description
Indication
Pneumonia, Burns, Meningitis, Endocarditis, Sinusitis, Septicaemia, Tonsillitis, Surgical Prophylaxis, Staphylococcal skin infections, Boils, Osteomyelitis, Enteritis, Wounds, Abscesses, Infected eczema, Infected acne
Administration
Should be taken on an empty stomach. Take on an empty stomach ½-1 hr before meals.
Reconstitution: Dissolve 250-500 mg in 5-10 mL water for inj or 1 g in 15-20 mL water for inj. For IV infusion, further dilute in suitable IV fluids (e.g. water for inj, NaCl 0.9%, glucose 5%, NaCl 0.18% w/ glucose 4%).
Adult Dose
Adults (including elderly patients):
Oral:
250-500mg 3-4 times a day.
Intravenous
IV 0.25-1 g 4 times/day, may double in severe cases. Up to 8 g/day in 3-4 divided doses may be given for osteomyelitis.
Up to 8 g/day in 4 divided doses for endocarditis in patients weighing 85 kg.
Child Dose
Children have been given doses of 12.5-25 mg/kg body weight 4 times a day.
Intravenous
2-10 years: Half of adult dose
Under 2 years: One fourth of adult dose
Renal Dose
Renal impairment:
CrCl (ml/min)
<10 Dosage adjustment may be necessary.
Contraindication
Hypersensitivity to penicillins. Porphyria.
Mode of Action
Flucloxacillin inhibits the 3rd and last step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. It is active against penicillinase-producing and non-penicillinase-producing staphylococci.
Precaution
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route; elderly. Hepatic impairment.
Side Effect
Hypersensitivity reactions including urticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis; hepatitis, cholestatic jaundice; agranulocytosis; phlebitis (IV infusion).
Potentially Fatal: Anaphylaxis. Stevens-Johnson syndrome
Interaction
May increase the risk of methotrexate toxicity. May decrease the efficacy of oestrogen-containing OC. Enhanced plasma concentrations w/ probenecid. Bacteriostatic drugs (e.g. chloramphenicol, tetracycline) may interfere w/ the bactericidal effect of flucloxacillin. May prolong bleeding time in patients on oral anticoagulants.
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