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Repose 25
Incepta Pharmaceuticals Ltd.
Generic: Sertraline Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Repose 25 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Repose 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Repose 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Repose 25 may cause side effects which could affect your ability to drive.
SAFE IF PRESCRIBED
Repose 25 is safe to use in patients with kidney disease. No dose adjustment of Repose 25 is recommended.
However, inform your doctor if you have an underlying kidney disease as you may be given a smaller dose initially and then increased slowly as required.
CAUTION
Repose 25 should be used with caution in patients with liver disease. Dose adjustment of Repose 25 may be needed. Please consult your doctor.
Use of Repose 25 is not recommended in patients with severe liver disease.
Medicine Overview of Repose 25mg Tablet
Introduction
Repose 25 is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is prescribed for depression and anxiety-related conditions like panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder (PTSD). Repose 25 is also used to treat premenstrual dysphoric disorder (depression and irritability before menstrual period in women). It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually....
... Show moreUses of Repose 25
- Depression
- Post traumatic stress disorder
- Obsessive-compulsive disorder
- Panic disorder
- Premenstrual dysphoric disorder
- Anxiety
Side effects of Repose 25
Common
- Delayed ejaculation
- Erectile dysfunction
- Indigestion
- Insomnia (difficulty in sleeping)
- Low sexual desire
- Nausea
- Tremor
- Diarrhea
- Increased sweating
- Loss of appetite
How to use Repose 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Repose 25 may be taken with or without food, but it is better to take it at a fixed time.
How Repose 25 works
Repose 25 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, obsessive-compulsive disorder, panic disorder, premenstrual dysphoric disorder and anxiety.
What if you forget to take Repose 25?
If you miss a dose of Repose 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Do not drive or do anything requiring concentration until you know how Repose 25 affects you.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- The addiction/dependence potential of Repose 25 is very less.
- Inform your doctor if you experience decreased sex drive or difficulty having an orgasm.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Major Depressive illness, Panic disorder, Premenstrual dysphoric disorder, Post-traumatic stress disorder, Obsessive-compulsive disorder, Social anxiety disorder
Administration
May be taken with or without food.
Adult Dose
Oral Major Depressive Disorder; Obsessive compulsive disorder Adult: Initially, 50 mg daily, may increase in increments of 50 mg at wkly intervals. Max: 200 mg daily. Panic disorder with or without agoraphobia; Posttraumatic stress disorder; Social anxiety disorder Adult: Initially, 25 mg daily, increased to 50 mg daily after a wk. May increase in increments of 50 mg at wkly intervals. Max: 200 mg daily. Premenstrual dysphoric disorder Adult: Initially, 50 mg daily, either throughout the menstrual cycle or during the luteal phase only. May increase in increments of 50 mg per menstrual cycle. Max: 150 mg daily (for continuous...
... Show moreChild Dose
Oral
Obsessive compulsive disorder
Child: 6-12 yr Initially, 25 mg once daily;
13-17 yr Initially, 50 mg once daily. May increase at intervals of at least 1 wk.
Max: 200 mg daily.
Renal Dose
Renal impairment: Dose adjustment not necessary
Contraindication
Sertraline is contraindicated in patients with a known hypersensitivity to Sertraline or any of the excipients of drug. Concurrent use or w/in 14 days of discontinuation of MAOIs (e.g. linezolid or IV methylene blue). Concomitant use w/ pimozide.
Mode of Action
Sertraline has a potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to sustained activity at the postsynaptic receptor sites and improvement of depression. Reduction of serotonin turnover (in brain) also contributes to its action. Its long half-life allows once daily admin.
Precaution
Patient w/ family history of bipolar disorder, mania or hypomania; previous seizure disorder or condition predisposing to seizures (e.g. alcoholism, brain damage); angle-closure glaucoma or history of glaucoma; risk factors for uric acid nephropathy, QTc prolongation. Patient w/ concurrent systemic illness (e.g. conditions that affect metabolism or haemodynamic process). Avoid abrupt withdrawal. Renal and hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor BMI (longitudinal monitoring), height, wt, unusual behavioural changes, signs and symptoms of serotonin syndrome.
Lactation
Distributed into milk; use caution (AAP states effect on nursing infants is unknown but may be of concern)
Side Effect
>10%
Diarrhea (13-24%),Nausea (13-30%),Headache (20-25%),Insomnia (12-28%),Ejaculation disorder (7-19%),Dizziness (6-17%),Dry mouth (6-16%),Fatigue (10-16%),Drowsiness (2-15%)
1-10%
Agitation (1-6%),Anorexia (5-10%),Anxiety (4%),Constipation (5-8%),Paresthesia (2%),Impotence (5-10%),Sweating (< 1%),Malaise (7-9%),Vomiting (4%),Pain (3-6%)
Frequency Not Defined
Asthenia,Back pain,Chest pain,Hypoesthesia,Increased appetite,Myalgia,Palpitations,Rhinitis,Tinnitus,Weight gain,Yawning
Interaction
May increase risk of delirium when used with antimuscarinics. Increased risk of extrapyramidal symptoms and neuroleptic malignant syndrome when used with aripiprazole. Serum levels may be reduced by carbamazepine. Concurrent use with dihydroergotamine or linezolid may lead to serotonin syndrome. May increase serum levels of lamotrigine and risk of toxicity. May increase serum levels of olanzapine, pimozide, risperidone, methadone, clozapine and amiodarone. Plasma levels may be increased by cimetidine and ritonavir. May increase the anticoagulant activity of warfarin and acenocoumarol.
Potentially Fatal: Concomitant admin with MAOIs can result in serious serotonin syndrome.
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