It is unsafe to consume alcohol with Siglimet XR 100/1000.
SAFE IF PRESCRIBED
Siglimet XR 100/1000 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Siglimet XR 100/1000 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Siglimet XR 100/1000 should be used with caution in patients with kidney disease. Dose adjustment of Siglimet XR 100/1000 may be needed. Please consult your doctor.
Use of Siglimet XR 100/1000 is, however, not recommended in patients with severe kidn...
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SAFE IF PRESCRIBED
Siglimet XR 100/1000 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Siglimet XR 100/1000 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Siglimet XR 100/1000mg+100mg Tablet
Introduction
Siglimet XR 100/1000 is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes such as kidney damage and blindness and may reduce your chance o...
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Uses of Siglimet XR 100/1000
Type 2 diabetes mellitus
Side effects of Siglimet XR 100/1000
Common
Diarrhea
Nausea
Vomiting
Upset stomach
Headache
Nasal congestion (stuffy nose)
Sore throat
Respiratory tract infection
Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
How to use Siglimet XR 100/1000
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Siglimet XR 100/1000 is to be taken with food.
How Siglimet XR 100/1000 works
Siglimet XR 100/1000 is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, th...
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Quick Tips
Take it with food to lower your chance of having an upset stomach.
Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.
Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Janumet XR CP T...
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Brief Description
Indication
Type 2 DM
Administration
Should be taken with food.
Adult Dose
Oral
Type 2 DM
The recommended starting dose in patients not currently treated with Metformin
Initially 50 mg/500 mg bd.
The starting dose in p...
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Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment
Obtain eGFR before starting metformin
eGFR <30 mL/min/1.73 m²: Contraindicated
eGFR 30-45 mL/min/1.73 m²: Not recommended to initi...
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Contraindication
Renal dysfunction, e.g., serum creatinine >1.5 mg/dL [males], >1.4 mg/dL [females] or abnormal creatinine clearance.
Metabolic acidosis, including d...
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Mode of Action
Sitagliptin: Dipeptidyl peptidase 4 (DPP-4) inhibitor, thereby increasing and prolonging incretin hormone activity which are inactivated by DPP-4 enzy...
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Precaution
Not for use in type 1 DM or treatment of ketoacidosis. Discontinue use if pancreatitis is suspected. Renal & hepatic impairment. Sulfonylurea- or insu...
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Side Effect
1-10%
Abdominal pain (2.2%),Diarrhea (2.4%),Hypoglycemia (2.1%),Nausea (1.3%),Vomiting (1.1%)
Frequency Not Defined
Exfoliative disorder of skin ...
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Interaction
Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid...
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.