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Sizonil 5
Healthcare Pharmaceuticals Ltd.
Generic: Trifluoperazine
Safety Advices
বাংলা
English
UNSAFE
Sizonil 5 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Sizonil 5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Sizonil 5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Sizonil 5 may cause side effects which could affect your ability to drive.
Sizonil 5 make u feel dizzy, drowsy or can cause blurred vision. This may affect your driving ability.
CONSULT YOUR DOCTOR
There is limited information available on the use of Sizonil 5 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Sizonil 5 in patients with liver disease. Please consult your doctor.
However, the use of Sizonil 5 is not considered safe in patients with liver disease as per the available data.
Medicine Overview of Sizonil 5mg Tablet
Introduction
Sizonil 5 is a prescription medicine used in the treatment of schizophrenia. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Sizonil 5 should be taken with food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the...
... Show moreUses of Sizonil 5
- Anxiety disorder
- Schizophrenia
Side effects of Sizonil 5
Common
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Sleepiness
- Dryness in mouth
- Abnormality of voluntary movements
- Weight gain
- Increased prolactin level in blood
- Urinary retention
- Constipation
- Muscle stiffness
- Tremor
How to use Sizonil 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sizonil 5 is to be taken with food.
How Sizonil 5 works
Sizonil 5 is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
Quick Tips
- You have been prescribed Trazine LS Tablet for the treatment of schizophrenia.
- It may cause less weight gain as compared to other similar medicines.
- Take it at bedtime to avoid feeling sleepy during the day.
- Use caution while driving or doing anything that requires concentration as Trazine LS Tablet can cause dizziness and sleepiness.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Avoid drinking alcohol while taking this medicine as it can cause increased sedation.
- Inform your doctor if you experience abnormal movements, particularly of the face, lips, jaw and tongue, while taking this medicine.
- It may increase your blood sugar and cholesterol level. Eat healthy, exercise regularly and monitor your blood levels regularly.
- Don't stop taking Trazine LS Tablet without talking to your doctor first as it may cause worsening of symptoms.
Brief Description
Indication
Anxiety, Psychoses, Nausea and vomiting, Schizophrenia
Administration
Should be taken with food.
Adult Dose
Oral
Psychoses, Schizophrenia
Adult:
Outpatient
1-2 mg PO q12hr
Inpatient
Initial: 2-5 mg PO q12hr
Maintenance Dose: 15-20 mg/day
Not to exceed 40mg/day
Short-term management of anxiety
Adult: 1-2 mg bid. Max: 6 mg daily. Max duration: 12 wk.
Elderly: Initiate at lower dose and increase gradually.
Child Dose
Schizophrenia/Psychosis
Inpatient
<6 years: Safety and efficacy not established
6-12 years old: 1 mg PO qDay or q12hr; not to exceed 15 mg/day
12 years old: 2-5 mg PO q12hr
Contraindication
Preexisting CNS depression and coma; bone marrow depression, blood dyscrasias, liver disease, hypersensitivity to phenothiazines, prolactin dependent tumours. Pregnancy (1st trimester), lactation.
Mode of Action
Trifluoperazine inhibits dopamine D2 receptors in the brain. It has weak anticholinergic and sedative effects but strong extrapyramidal and antiemetic effects. It controls severely disturbed, agitated or violent behaviour but may also be used for nonpsychotic anxiety.
Precaution
Cardiovascular disease, epilepsy, angle-closure glaucoma, exposure to extreme temperatures, elderly, parkinson's disease, myasthenia gravis, benign prostatic hyperplasia, DM, renal amd hepatic impairment. Discontinue trifluoperazine at least 48 hr before myelography and do not resume for at least 24 hr after procedure. Do not use trifluoperazine in control of nausea and vomiting occurring either prior to myelography or postprocedure with metrizamide. Pregnancy.
Side Effect
EPS (60%; muscle stiffness, dystonia, parkinsonism, tardive dyskinesia, akathisia), Drowsiness, dry mouth, blurred vision, dizziness, sedation, antimuscarinic affects, postural hypotension, akathisia, muscle weakness, anorexia, insomnia, rash, amenorrhoea, fatigue, increased prolactin levels.
Potentially Fatal: Neuroleptic malignant syndrome, blood dyscrasias.
Interaction
Increased CNS depression with CNS depressants such as opiates or other analgesics, barbiturates or other sedatives, general anaesthetics, or alcohol. Increased risk of side effects with drugs with antimuscarinic properties e.g. TCA, antiparkinsonian drugs. Antagonised effects of dopaminergic drugs such as levodopa. Increased risk of hypotension with antihypertensives, trazodone. Reverses antihypertensive effect of guanethidine. Increased risk of severe extrapyramidal side-effects or severe neurotoxicity with lithium. Possible decrease in absorption with antacids.
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