Insomnia
Recommended starting dose: 10 mg PO taken no more than once per night and within 30 minutes of going to bed.
Not to exceed 20 mg once daily.
Hepatic impairment
Mild-to-moderate: No dosage adjustment required
Severe: Not recommended
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: No dosage adjustment required
Contraindication
Hypersensitivity. Narcolepsy
Mode of Action
Orexin receptor antagonist; orexin, also called hypocretin, is a neurotransmitter that regulates arousal, wakefulness, and appetite
Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to s...
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Precaution
Can impair daytime wakefulness; CNS depressant effects can last for up to several days after discontinuation
Can impair driving skills and may increase the risk of falling asleep while driving
Dosage adjustments of suvorexant and concomitant CNS de...
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