It is not known whether it is safe to consume alcohol with Toposar. Please consult your doctor.
CONSULT YOUR DOCTOR
Toposar is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Toposar is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Toposar does not usually affect your ability to drive.
CAUTION
Toposar should be used with caution in patients with kidney disease. Dose adjustment of Toposar may be needed. Please consult your doctor.
Use of Toposar is not recommended in patients with end-stage kidney disease.
CAUTION
Toposar should be used with caution in patients with liver disease. Dose adjustment of Toposar may be needed. Please consult your doctor.
Use of Toposar is not recommended in patients with severe liver disease.
Medicine Overview of Toposar 100mg/5ml Injection
Introduction
Toposar is used to treat different cancers of lung, and testicles. It is also sometimes used to treat some other kinds of cancer in both men and women. It can be used on its own, or sometimes given together with certain other medicines as part of com ... Show more
Uses of Toposar
Small cell lung cancer
Testicular cancer
Side effects of Toposar
Common
Anemia (low number of red blood cells)
Decreased blood cells (red cells, white cells, and platelets)
Decreased white blood cell count
Diarrhea
Hair loss
Liver damage
Low blood platelets
Nausea
Rash
Stomatitis (Inflammation of the mouth)
Vomiting
How to use Toposar
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Toposar works
Toposar is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Brief Description
Indication
Lung cancer, Testicular cancer
Adult Dose
Intravenous
Testicular Cancer
50-100 mg/m²/day IV on days 1-5, OR
100 mg/m²/day IV on days 1, 3, 5
Repeat q3-4week
Small-Cell Lung Cancer
35 ... Show more
Renal Dose
Renal Impairment
CrCl >50 mL/min: Dose adjustment not necessary
CrCl 15-50 mL/min: 75% of regular dose
CrCl < 15 mL/min: Not studied; consider furt ... Show more
Contraindication
Hypersensitivity, pregnancy, lactation.
Mode of Action
Etoposide is a derivative of podophyllotoxin that inhibits DNA synthesis resulting in the arrest of the cell cycle. At low doses, it inhibits cells fr ... Show more
Precaution
Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased ... Show more
Side Effect
>10%
Leukopenia (60-91%),Nausea and Vomiting (30-40%),Thrombocytopenia (28-41%),Alopecia (20-90%),Anorexia (13%),Diarrhea (13%),Leukopenia (60-91%),A ... Show more
Pregnancy Category Note
Pregnancy: Based on animal data and its mechanism of action, etoposide can cause fetal harm when administered to a pregnant woman; etoposide, the acti ... Show more
Interaction
Synergism with other cytotoxic drugs. Caution when admin with drugs that inhibit phosphatase activity. Cyclosporin A may reduce the clearance of etopo ... Show more
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.