ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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Incepta Pharmaceuticals Ltd.
Generic: Clozapine
৳ 22.74
৳ 25
9% OFF Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Zapenia 25.
SAFE IF PRESCRIBED
Zapenia 25 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Zapenia 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
If Zapenia 25 is used, monitor the baby for excessive sedation. Periodically, keep a check on the baby's white blood cell count as well.
UNSAFE
Zapenia 25 may cause side effects which could affect your ability to drive.
You may feel tired, drowsy, dizzy or you may feel faint while taking ClozapineZapenia 25, especially during the early stages of treatment. This may affect your driving ability.
CAUTION
Zapenia 25 should be used with caution in patients with kidney disease. Dose adjustment of Zapenia 25 may be needed. Please consult your doctor.
Use of Zapenia 25 is may not be advised in patients with severe kidney disease.
CAUTION
Zapenia 25 should be used with caution in patients with liver disease. Dose adjustment of Zapenia 25 may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advisable. Inform your doctor if you experience nausea, vomiting and/or weight loss while taking this medicine.
Medicine Overview of Zapenia 25mg Tablet
Introduction
Zapenia 25 is a prescription medicine used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave). Zapenia 25 may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses...
... Show moreUses of Zapenia 25
- Schizophrenia
Side effects of Zapenia 25
Common
- Increased sweating
- Visual impairment
- Decreased blood pressure
How to use Zapenia 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zapenia 25 may be taken with or without food, but it is better to take it at a fixed time.
How Zapenia 25 works
Zapenia 25 is an atypical antipsychotics. It works by modulating the action of certain chemical messengers in the brain that affects thoughts.
Quick Tips
- Zapenia 25 helps treat schizophrenia in people for whom other medicines are ineffective or not tolerated.
- Take it with or without food, preferably at the same time everyday.
- It can cause dizziness and sleepiness. Be cautious while driving or doing anything that requires concentration.
- It may cause low blood pressure and dehydration. Drink plenty of fluids and rise slowly from a sitting or lying position.
- It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
- Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
- Do not stop taking Zapenia 25 without talking to your doctor first as it may cause worsening of symptoms.
Brief Description
Indication
Indicated for reducing risk of recurrent suicidal behavior in patients with schizophrenia, or schizoaffective disorder in patients who are judged to be at chronic risk to re-experience suicidal behavior
Treatment-resistant schizophrenia, in patients who fail to respond adequately to standard antipsychotic treatment
Psychotic disorders in people with Parkinson's disease, when standard treatment has failed to control symptoms.
... Show moreAdministration
May be taken with or without food.
Adult Dose
Adults: PO: Schizophrenia 12.5 mg PO once daily or q12hr initially; increased daily in increments of 25-50 mg/day, if well tolerated, to achieve target dosage of 300-450 mg/day by end of 2 weeks On occasion, may have to be increased to 600-900 mg/day to obtain acceptable response Maintenance: Generally, patients who respond should continue maintenance treatment on their effective dose beyond the acute episode Psychoses in Parkinson's disease Initial: 12.5 mg/day at night, increase gradually in steps of 12.5 mg up to twice weekly. Usual range: 25-37.5 mg/day at bedtime. Max: 100 mg/day in 1-2 divided doses. Elderly: Lower initial...
... Show moreRenal Dose
Renal impairment: Severe: Contraindicated.
Contraindication
History of bone marrow disorders including agranulocytosis, circulatory collapse, alcoholic or toxic psychosis, drug intoxication, uncontrolled epilepsy, severe renal, hepatic or cardiac disease; paralytic ileus. Pregnancy and lactation.
Mode of Action
Clozapine has relatively weak dopamine receptor-blocking activity at D1, D2, D3 and D5 receptors but has high affinity for the D4 receptor. It has also blocking effects on serotonin, ?-adrenergic histamine H1 and cholinergic receptors.
Precaution
Medication should not be stopped abruptly; should be tapered off over 1-2 weeks. If conditions warrant abrupt discontinuation (leukopenia, myocarditis, cardiomyopathy), monitor patient for psychosis and cholinergic rebound (headache, nausea, vomiting, diarrhea). Elderly patients are more susceptible to adverse effects (including agranulocytosis, cardiovascular, anticholinergic, and tardive dyskinesia). Significant risk of agranulocytosis, potentially life-threatening. Leucocyte counts should be monitored regularly and for at least 4 wk after treatment discontinuation. Renal, hepatic or cardiac impairment; prostatic enlargement, narrow-angle glaucoma; elderly; immobilised patients.
Lactation: Drug enters breast milk; not recommended (American Academy of Pediatrics Committee states that this is "of concern")
... Show moreSide Effect
Commonly: Sedation, wt gain, reversible neutropenia, eosinophilia, tachycardia, orthostatic hypotension, dizziness, hypersalivation at night, headache, nausea, vomiting, constipation, urinary incontinence and retention, fatigue, transient fever, abnormalities of glucose homoeostasis and the onset of DM, obsessive compulsive symptoms.
Rarely: Anaemia, thrombocytopenia, thrombocythaemia, extrapyramidal disorders including tardive dyskinesia, circulatory collapse w/ cardiac and resp arrest, HTN, dysphagia, parotid gland enlargement, confusion, delirium, thromboembolism, acute pancreatitis, hepatitis and cholestatic jaundice.
Potentially Fatal: Agranulocytosis, myocarditis, cardiomyopathy, cardiac arrhythmias, pericarditis/pericardial effusion, neuroleptic malignant syndrome, pulmonary embolism, lower resp tract infection.
... Show morePregnancy Category Note
Pregnancy category: B
Neonates exposed to antipsychotic drugs during 3rd trimester of pregnancy are at risk for EPS or withdrawal symptoms after delivery; these complications vary in severity, with some being self-limited and others requiring ICU support and prolonged hospitalization
Lactation: Drug enters breast milk; not recommended (American Academy of Pediatrics Committee states that this is "of concern")
... Show moreInteraction
Increased risk and/or severity of bone marrow suppression w/ bone marrow suppressants (e.g. carbamazepine, chloramphenicol), sulfonamides (e.g. co-trimoxazole), pyrazolone analgesics (e.g. phenylbutazone), penicillamine, cytotoxic agents or long-acting depot inj of antipsychotics. Concomitant use w/ benzodiazepines may increase risk of circulatory collapse which may lead to cardiac and/or resp arrest. Additive CNS depression and cognitive and motor performance interference w/ MAOIs and CNS depressants including antihistamines, benzodiazepines and opioid analgesics. May potentiate effects of anticholinergics or antihypertensives. Increased plasma concentration of highly protein bound substances (e.g. warfarin, digoxin). Decreased plasma concentrations w/ phenytoin. Concomitant use w/ lithium can increase the risk...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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Incepta Pharmaceuticals Ltd.
Generic: Clozapine
৳ 22.74
৳ 25
9% OFF Alternative Brands For Zapenia 25
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.