12-24 Hours
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Plagrin Plus
Renata Limited
Generic: Aspirin + Clopidogrel
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Plagrin Plus.
CONSULT YOUR DOCTOR
Plagrin Plus is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Plagrin Plus is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Plagrin Plus may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Plagrin Plus should be used with caution in patients with kidney disease. Dose adjustment of Plagrin Plus may be needed. Please consult your doctor.
Use of Plagrin Plus is not recommended in patients with severe kidney disease.
CAUTION
Plagrin Plus should be used with caution in patients with liver disease. Dose adjustment of Plagrin Plus may be needed. Please consult your doctor.
Use of Plagrin Plus is not recommended in patients with severe liver disease.
Medicine Overview of Plagrin Plus 75mg+75mg Tablet
Introduction
Plagrin Plus is a combination of two antiplatelet medicines or blood thinner used to reduce the formation of harmful blood clots in blood vessels. This helps to prevent a heart attack or stroke in people with heart disease. Plagrin Plus should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do...
... Show moreUses of Plagrin Plus
- Heart attack prevention
- Stroke prevention
Side effects of Plagrin Plus
Common
- Abdominal pain
- Bruise
- Diarrhea
- Gastrointestinal bleeding
- Increased bleeding tendency
- Nosebleeds
How to use Plagrin Plus
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Plagrin Plus is to be taken with food.
How Plagrin Plus works
Plagrin Plus is a combination of two antiplatelet medicines: Aspirin and Clopidogrel which prevent heart attack. They work by preventing the platelets from sticking together and decrease the formation of harmful blood clots.
Quick Tips
- You have been prescribed Plagrin Plus to lower your risk of heart attack and stroke.
- Take it with food to avoid an upset stomach.
- It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails or using sharp objects.
- Let your doctor know you are taking Plagrin Plus before undergoing any surgical procedure.
Brief Description
Indication
Adult: PO Prevention of ischaemic events Per tab contains clopidogrel 75 mg and aspirin 75 mg: 1 tab once daily. Acute coronary syndrome Per tab contains clopidogrel 75 mg and aspirin 75 mg: Loading dose: 4 tab; maintenance: 1 tab/day.
Hepatic impairment: Severe hepatic impairment: Avoid use.
Administration
Aspirin: Corticosteroids, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Use with coumarins, anagrelide, agatroban, LMWH, bivalirudin, dasatinib, iloprost, lepirudin and tenecteplase may increase the risk of bleeding. Clopidogrel: Co-administration of clopidogrel with NSAIDs may increase the risk of stomach and intestinal bleeding. There is an increased risk of bleeding with coumarins, agatroban, dasatinib, heparin, LMWH, gingko biloba and iloprost. Increased risk of bleeding if clopidogrel and drotrecogin alfa are given within 7 days. May increase bupropion level and side effects (lightheadedness , GI discomfort).
Potentially Fatal: Aspirin and clopidogrel: Increased risk of bleeding with dabigatran.
Adult Dose
History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion or heavy ethanol consumption; asthma or allergic disorders; tinnitus; dehydrated patients; uncontrolled hypertension; impaired renal or hepatic function; children and elderly; pregnancy. Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions. Increased risk of Reye's syndrome when used in patients with chicken pox, influenza or flu symptoms. Caution when used in patients with nasal allergies or nasal polyps. For patients undergoing elective surgery and an antiplatelet effect is not needed, clopidogrel should be discontinued 7-10 days before surgery.
Renal Dose
Aspirin inhibits the formation of thromboxane A2 in the platelets. This inhibits platelet aggregation and coagulation. This action lasts until the enzyme cyclo-oxygenase is regenerated in the platelets. Clopidogrel is a prodrug and is metabolised an active thiol metabolite. The active metabolite selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GP IIb/IIIa complex, thereby inhibiting platelet aggregation.
Mode of Action
Should be taken with food.
Precaution
Acute coronary syndrome, TIA, Ischaemic events, MI, Stroke
Side Effect
Renal impairment:
CrCl (ml/min)
<10 Avoid use.
Pregnancy Category Note
Aspirin: GI disturbances, epigastric discomfort, prolonged bleeding time, rhinitis, urticaria; angioedema, salicylism, tinnitus. Clopidogrel: Dyspepsia, abdominal pain, nausea, vomiting, flatulence, constipation, gastritis, gastric and duodenal ulcers. Serious events include bleeding and GI haemorrhage. GI upset, diarrhoea, paraesthesia, vertigo, headache, dizziness, leucopaenia, eosinophilia, rash and pruritus.
Potentially Fatal: Aspirin: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (childn <12 yrs). Hepatotoxicity; CNS depression, which may lead to coma; CV collapse, resp failure; paroxysmal bronchospasm and dyspnoea. Clopidogrel: Bleeding disorders including GI intracranial haemorrhage and thrombotic thrombocytopenic purpura.
Interaction
Hypersensitivity to aspirin, NSAIDs or clopidogrel; active peptic ulceration; children <12 yr; patients with haemophilia or haemorrhagic disorders; gout; severe renal or hepatic impairment; lactation.
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