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Bendamax
Beacon Pharmaceuticals PLC
Generic: Bendamustine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Bendamax. Please consult your doctor.
CONSULT YOUR DOCTOR
Bendamax is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Bendamax is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
CONSULT YOUR DOCTOR
It is not known whether Bendamax alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Bendamax is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bendamax may not be needed in these patients. Please consult your doctor.
CAUTION
Bendamax should be used with caution in patients with liver disease. Dose adjustment of Bendamax may be needed. Please consult your doctor.
Medicine Overview of Bendamax 25mg/vial Injection
Introduction
Bendamax is used to treat cancer of the lymphatic system such as Non-Hodgkin's Lymphoma (NHL). It may also be used to treat other types of cancer as determined by your doctor. It can be used alone, or together with certain other medicines as part of combination chemotherapy. Bendamax is given as an injection into vein under the supervision of a doctor and should not be self-administered. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or...
... Show moreUses of Bendamax
- Non-Hodgkin's lymphoma
- Blood cancer
- Multiple myeloma
Side effects of Bendamax
Common
- Anemia (low number of red blood cells)
- Decreased white blood cell count
- Infection
- Fatigue
- Nausea
- Fever
- Vomiting
- Low blood platelets
- Mucosal inflammation
How to use Bendamax
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Bendamax works
Bendamax is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Bendamax?
If you miss a dose of Bendamax, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Bendamax is given as an injection into vein under the supervision of a doctor.
Brief Description
Indication
Chronic lymphocytic leukaemia, Non-hodgkin's lymphoma, Multiple myeloma
Adult Dose
Intravenous Chronic lymphocytic leukaemia Adult: 100 mg/m2 infused over 30-60 min on days 1 and 2 of a 28-day cycle for up to 6 cycles. For severe haematological or non-haematological toxicity: Reduce dose to 50 mg/m2 on days 1 and 2 of each cycle. If severe haematological toxicity recurs, further reduce dose to 25 mg/m2 on days 1 and 2 of each cycle. May consider dose re-escalation in subsequent cycles. Multiple myeloma Adult: 120-150 mg/m2 infused over 30-60 min on days 1 and 2 of a 28-day cycle. IV or oral prednisone may be given at a dose of 60...
... Show moreRenal Dose
Renal Impairment
Mild-to-moderate: Use caution
CrCl <40 mL/min: Not recommended
Contraindication
Patient w/ history of hypersensitivity (e.g. anaphylaxis and anaphylactoid reactions); jaundice, severe bone marrow suppression, low leukocyte or platelet count. Severe hepatic impairment. Major surgery <30 days prior to treatment.
Mode of Action
Bendamustine is an antineoplastic alkylating agent. It interferes w/ DNA replication and RNA transcription that leads to disruption of nucleic acid function. It is also active against inert and dividing cells.
Precaution
Interrupt if severe infusion reactions Mild-mod renal impairment, mild hepatic impairment Possibility of anaphylactic/infusion reactions: severe in rare cases Myelosuppression may occur; delay or reduce dose; restart treatment based on ANC and platelet count recovery; complications of myelosuppression may lead to death Monitor for fever and other signs of infection and treat promptly Severe infusion and anaphylactic reactions reported; monitor clinically and discontinue therapy; premedicate in subsequent cycles for milder reactions Tumor lysis syndrome reported; acute renal failure and death may occur; anticipate and use supportive measures Discontinue for severe skin reactions; cases of SJS and TEN, some fatal, reported...
... Show moreSide Effect
>10% Lymphopenia (68-99%),Leukopenia (61-94%; grade 3/4, 28-56%),Anemia (88-89%; grades 3/4 11-13%),Thrombocytopenia (77-86%; grade 3/4, 11-25%),,Neutropenia (75-86%; grade 3/4, 43-60%),Nausea (20-75%),Fatigue (9-57%),Vomiting (16-40%),Diarrhea (9-37%),Bilirubin increased (<34%; grade 3/4, 3%),Constipation (<29%),Fever (24-34%),Pyrexia (24%),Anorexia (<23%),Cough (4-22%)Headache (<21%),Weight loss (7-18%),Dehydration (<16%),Rash (8-16%),Stomatitis (<15%),Back pain (<14%),Dizziness (<14%),Chills (6-14%),Peripheral edema (13%),Abdominal pain (5-13%),Insomnia (<13%),Dyspepsia (<11%),Weakness (8-11%) 1-10% Upper respiratory infection (10%),Gastroesophageal reflux disease (<10%),Urinary tract infection (<10%),Xerostomia (9%),Hypokalemia (<9%),Anxiety (8%),Hyperuricemia (<7%),Tachycardia (<7%),Taste alteration (<7%),Arthralgia (<6%),Chest pain (<6%),Depression (<6%),Hypotension (<6%),Injection site pain (<6%),Pain (<6%),Pruritus (5-6%),Febrile neutropenia (3-6%),Rash (5%) Potentially Fatal: Myelosuppression, tumour lysis syndrome which may lead to acute renal failure, infections (e.g. sepsis, pneumonia, septic shock),...
... Show morePregnancy Category Note
Pregnancy There are no available data on use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; advise pregnant women of potential risk to fetus Pregnancy testing recommended for females of reproductive potential prior to initiation of therapy Contraception Therapy can cause embryo-fetal harm when administered to pregnant women; advise female patients of reproductive potential to use effective contraception during treatment and for 6 months after final dose Based on genotoxicity findings, advise males with female partners of reproductive potential to use effective contraception during treatment with drug and...
... Show moreInteraction
May increase plasma levels w/ CYP1A2 inhibitors (e.g. ciprofloxacin, fluvoxamine). May reduce plasma levels w/ CYP1A2 inducers (e.g. omeprazole and tobacco smoking).
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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