Endoxan is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Endoxan is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Endoxan may cause side effects which could affect your ability to drive.
Endoxan may cause undesirable effects (e.g., dizziness, blurred vision, visual impairment) which could affect the ability to drive.
CAUTION
Endoxan should be used with caution in patients with severe kidney disease. Dose adjustment of Endoxan may be needed. Please consult your doctor.
CAUTION
Endoxan should be used with caution in patients with liver disease. Dose adjustment of Endoxan may be needed. Please consult your doctor.
Medicine Overview of Endoxan 500mg/vial Injection
Introduction
Endoxan is used in the treatment of different kinds of cancers. It is also used to treat kidney disease known as nephrotic syndrome in children after other treatments have not worked. It may be also used to treat other conditions, as determined by th ... Show more
Uses of Endoxan
Cancer
Nephrotic syndrome
Side effects of Endoxan
Common
Vomiting
Nausea
Hair loss
Fever
Blood in urine
Diarrhea
Decreased white blood cell count (neutrophils)
How to use Endoxan
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Endoxan is to be taken with food.
How Endoxan works
Endoxan is an anti-cancer medication. It is an alkylating agent which works by damaging the genetic material (DNA and RNA) of the cancer cells, thereby stopping their growth and multiplication. This is how it works against cancer.
Quick Tips
Endoxan helps in the treatment of cancer.
Drink plenty of fluids or urinate frequently to prevent urinary problems while taking this medication.
Take it with food if you experience irritation of the stomach, preferably in the morning.
Your doctor may get regular blood tests to monitor your blood counts while on treatment with this medication.
You are more likely to get sick or heal slower while taking this medication. Talk to your doctor before getting any vaccines.
Contact your doctor immediately if you experience difficulty in urinating or blood in urine while on treatment with this medication.
Do not take Endoxan if you are pregnant or breastfeeding.
Use effective contraception method to prevent pregnancy while taking this medicine.
Brief Description
Indication
Bone marrow transplantation, malignancies, lymphomas, brain cancer, leukemia, systemic lupus erythematosus, minimal change disease, severe rheumatoid ... Show more
Administration
Should be taken on an empty stomach. Preferably taken on an empty stomach, but may be taken w/ meals to minimise GI irritation. Ensure adequate fluid ... Show more
Adult Dose
Malignant Diseases
IV (intermittent therapy): 40-50 mg/kg (400-1800 mg/m²) divided over 2-5 days; may be repeated at intervals of 2-4 weeks
IV (co ... Show more
Child Dose
Malignant Diseases
IV (intermittent therapy): 40-50 mg/kg (400-1800 mg/m²) divided over 2-5 days; may be repeated at intervals of 2-4 weeks
IV (co ... Show more
Contraindication
Bladder haemorrhage. Patients with bone-marrow aplasia, acute infection, drug- or radiation-induced urothelial toxicity. Porphyria. Pregnancy and lact ... Show more
Mode of Action
Cyclophosphamide is a prodrug which is converted in the body to the active metabolites. It acts at any stage of the cell cycle but its main action is ... Show more
Precaution
Blood disorders. Elderly or debilitated patients. Diabetic patients. Renal or hepatic impairment or who have gone adrenaloctomy. Previous treatment wi ... Show more
Side Effect
Alopecia, skin and nails hyperpigmentation, nausea and vomiting, mucositis, inappropriate antidiuretic hormone secretion, carbohydrate metabolism dist ... Show more
Pregnancy Category Note
Pregnancy
Based on mechanism of action and published reports of effects in pregnant patients or animals, drug can cause fetal harm when administered ... Show more
Interaction
Increased risk of cardiotoxicity w/ doxorubicin or other cardiotoxic drugs. May increase incidence of mucositis w/ protease inhibitors. May increase h ... Show more
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.