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Cefazol 500
Incepta Pharmaceuticals Ltd.
Generic: Cefazolin
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Cefazol 500 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Cefazol 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Cefazol 500 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Cefazol 500, since it may have possible effects such as rash and diarrhea.
UNSAFE
Cefazol 500 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Cefazol 500 should be used with caution in patients with kidney disease. Dose adjustment of Cefazol 500 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Cefazol 500 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Cefazol 500 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Cefazol 500mg Injection
Introduction
Cefazol 500 is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), ear, urinary tract, skin and soft tissues, bones and joints, blood, and heart. It is also used to prevent infections during surgery. Cefazol 500 fights and stops the growth of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a slow drip (intravenous infusion) under the supervision of a healthcare professional. Your doctor will decide the correct dose for you. You should use this medicine regularly at evenly spaced...
... Show moreUses of Cefazol 500
- Bacterial infections
Side effects of Cefazol 500
Common
- Rash
- Injection site reactions (pain, swelling, redness)
- Allergic reaction
- Nausea
- Indigestion
- Diarrhea
How to use Cefazol 500
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Cefazol 500 works
Cefazol 500 is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Cefazol 500?
If you miss a dose of Cefazol 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Cefazol 500 to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Discontinue Cefazol 500 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Cefazol 500 as it may cause increased side effects.
Brief Description
Indication
Infections With Gram-Positive Cocci, Mild-to-Moderate Cholecystitis, Uncomplicated Urinary Tract Infection, Prophylaxis against surgical infection, Endocarditis, Community-Acquired Pneumonia
Administration
IV Preparation Reconstitute 500 mg or 1 g with 2 mL or 2.5 mL SWI, respectively, to provide solutions containing approximately 225 or 330 mg/mL IV push: Further dilute in approximately 5 mL of SWI or according to manufacturer's directions Infusion: Dilute reconstituted 500 mg or 1 g solution in 50-100 mL NS or D5W IM Preparation Reconstitute 500 mg or 1 g with 2 mL or 2.5 mL SWI, respectively, to provide solutions containing approximately 225 or 330 mg/mL IV Administration IV push Administer directly into vein, and infuse over 3-5 minutes or slowly into tubing of compatible IV...
... Show moreAdult Dose
Parenteral Susceptible infections Adult: Mild: 0.25-0.5 g 8 hrly. Moderate to severe: 0.5-1 g 6-8 hrly. Severe, life-threatening: 1-1.5 g 6 hrly. Max: 12 g daily. All doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Mild Infections With Gram-Positive Cocci 250-500 mg IV q8hr Mild-to-Moderate Cholecystitis 1-2 g IV q8hr for 4-7 days Uncomplicated Urinary Tract Infection 1 g IV q12hr Preparation for Surgery Prophylaxis against infection Preoperatively: 1-2 g IV/IM ?60 minutes before procedure (may be repeated in 2-5 hours intraoperatively) Postoperatively: 0.5-1 g IV q6-8hr for...
... Show moreChild Dose
Parenteral Susceptible infections Child: >1 yr 25-50 mg/kg daily in 3 or 4 divided doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 100 mg/kg daily in divided doses for severe infections. Infections With Gram-Positive Cocci Neonates (7 days, 7 days, >2 kg: 60 mg/kg/day IV/IM divided q8hr Infants & children 25-100 mg/kg/day IV/IM divided q6-8hr; not to exceed 6 g/day Endocarditis Prophylaxis 50 mg/kg IV/IM ?30-60 minutes before procedure; not to exceed 1 g AHA guidelines: Endocarditis prophylaxis recommended only for high-risk patients Community-Acquired Pneumonia >3 months...
... Show moreRenal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<10 Half the usual dose 18-24 hrly.
11-34 Half the usual dose 12 hrly.
35-54 Usual dose at intervals of at least 8 hr.
Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Cefazolin binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
Patient w/ history of hypersensitivity to penicillins, GI disease particularly colitis, seizure disorder. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor prothrombin time; renal, hepatic and haematological function; monitor for signs of anaphylaxis during 1st dose.
Lactation: Drug excreted in breast milk; use with caution (American Academy of Pediatrics committee states that drug is compatible with nursing)
Side Effect
Diarrhoea, oral candidiasis, vomiting, nausea, stomach cramps, anorexia; eosinophilia, itching, drug fever, skin rash, Stevens-Johnson syndrome; neutropenia, leucopenia, thrombocytopenia, thrombocythemia; transient elevation in SGOT, SGPT and alkaline phosphatase levels; hepatitis; increased BUN and creatinine levels, renal failure; phlebitis, induration; genital and anal pruritus (e.g. vulvar pruritus, genital moniliasis, vaginitis).
Potentially Fatal: Anaphylaxis, pseudomembranous colitis.
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug excreted in breast milk; use with caution (American Academy of Pediatrics committee states that drug is compatible with nursing)
Interaction
May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin). May diminish the therapeutic effect of Na picosulfate, BCG and typhoid vaccine. May decrease the protein binding of fosphenytoin and phenytoin. Probenecid may decrease renal tubular secretion of cefazolin, resulting in increased and prolonged blood levels. May increase the nephrotoxic effects of aminoglycosides.
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