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Novo Nordisk
Generic: Insulin degludec + Insulin aspart 70/30 premixed
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Ryzodeg Penfill.
CONSULT YOUR DOCTOR
Ryzodeg Penfill may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Ryzodeg Penfill is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Ryzodeg Penfill should be used with caution in patients with kidney disease. Dose adjustment of Ryzodeg Penfill may be needed. Please consult your doctor.
Regular monitoring of blood glucose levels is recommended for dose adjustment.
CAUTION
Ryzodeg Penfill should be used with caution in patients with liver disease. Dose adjustment of Ryzodeg Penfill may be needed. Please consult your doctor.
Frequent and regular monitoring of blood glucose levels is advised.
Medicine Overview of Ryzodeg Penfill 100IU/ml Injection
Introduction
Ryzodeg Penfill is a combination of two medicines, a long-acting and a rapid-acting type of insulin used to treat types 1 and 2 diabetes mellitus in both adults and children. It provides a steady level of insulin in the body for an entire day and helps control blood sugar levels. Ryzodeg Penfill can be prescribed by itself or along with other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. You should use this medicine regularly as per the dose advised to get the most benefit. It is usually taken once...
... Show moreUses of Ryzodeg Penfill
- Diabetes mellitus (Type 1 & Type 2)
Side effects of Ryzodeg Penfill
Common
- Rash
- Weight gain
- Injection site allergic reaction
- Lipodystrophy (skin thickening or pits at the injection site)
- Edema (swelling)
- Itching
- Hypoglycemia (low blood glucose level)
How to use Ryzodeg Penfill
Your doctor or nurse will guide you how to use this medicine.
How Ryzodeg Penfill works
Ryzodeg Penfill is a combination of two insulin preparations: Insulin degludec and insulin aspart. Insulin degludec has a prolonged duration of action while insulin aspart has a fast onset of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells, and suppressing the production of sugar in the liver.
Quick Tips
- Take it 15 minutes before a meal or within 20 minutes after starting a meal.
- Injection below the skin of the abdomen results in faster absorption as compared to other injection sites such as skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
- Injection sites must be rotated to prevent hard lumps from developing at one site.
- Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
- Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
- Do not share your insulin device with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
- Opened vials / cartridge are good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
Brief Description
Indication
Treatment of diabetes mellitus in adults.
Administration
Administer subcutaneously in the upper arm, thigh or abdominal wall. A subcutaneous injection into the abdominal wall results in a faster absorption than from other injection sites.
Inject SC once or twice daily with any main meal
Administer a rapid- or a short-acting insulin at other meals if needed
Patients with type 1 diabetes, will generally require a rapid- or short-acting insulin at meals when insulin degludec/insulin aspart 70/30 is not administered for optimal glucose control
Adult Dose
Subcutaneous Prefilled pen Insulin degludec 70 units/insulin aspart 30 units per mL (ie, 100 units/mL for combination) Starting dose in insulin naïve patients Type 1 diabetes mellitus: One third to one half of the total daily insulin dose; as a general rule; the remainder of the total daily insulin dose should be administered as a short- or rapid-acting insulin divided between each daily meal; 0.2-0.4 units/kg can be used to calculate the initial total daily insulin dose in insulin-naïve patients with type 1 diabetes Type 2 diabetes mellitus: 10 units SC once daily Starting dose in patients with types 1...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Dose adjustments may be needed.
Contraindication
Hypersensitivity to the active substances or to any of the excipients.
Mode of Action
Insulin degludec and insulin aspart binds specifically to the human insulin receptor and results in the same pharmacological effects as human insulin.
The blood glucose-lowering effect of insulin is due to the facilitated uptake of glucose following the binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver.
Precaution
Hypoglycaemia Omission of a meal or unplanned strenuous physical exercise may lead to hypoglycaemia. Hypoglycaemia may occur if the insulin dose is too high in relation to the insulin requirement. Concomitant illness, especially infections and fever, usually increases the patient's insulin requirement. Concomitant diseases in the kidney, liver or diseases affecting the adrenal, pituitary or thyroid gland may require changes in the insulin dose. Hyperglycaemia Administration of rapid-acting insulin is recommended in situations with severe hyperglycaemia. Inadequate dosing and/or discontinuation of treatment in patients requiring insulin may lead to hyperglycaemia and potentially to diabetic ketoacidosis. Furthermore, concomitant illness, especially infections,...
... Show moreSide Effect
>10%
Nasopharyngitis (11.1-24.6%),Severe hypoglycemia (0.4-13.3%)
1-10%
Headache (5.6-9.7%),URT infection (5.7-9.1%),Influenza (6.9%),Peripheral edema (1.8-2.2%),Injection site reaction (2%)
<1%
Allergic reaction,Lipodystrophy
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
Novo Nordisk
Generic: Insulin degludec + Insulin aspart 70/30 premixed
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.
