ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

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Avalet 20

Name: Avalet 20mg Tablet
Brand: Drug International Ltd.
SKU: 38909
Price: 2497.89 BDT
Availability: InStock
Rating: 4.9 (5 reviews)

Tablet - (20mg)

Drug International Ltd.

Generic: Avatrombopag

Medicine Overview of Avalet 20mg Tablet

বাংলা

English

Indication

Thrombocytopenia

Administration

Take with food

Adult Dose

Thrombocytopenia Patients with chronic liver disease Indicated for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a procedure Taken orally once daily for 5 consecutive days with food Initiate dosing 10-13 days prior to the scheduled procedure Patients should undergo their procedure 5-8 days after the last dose Dose based on preprocedure platelet count Platelet count 400 x10^9/L: Stop avatrombopag and increase platelet monitoring to twice weekly; may reinitiated by decreasing 1 dose level when platelets 400 x10^9/L after 2 weeks at 20 mg/week: Discontinue avatrombopag Dose levels for titration in ITP Dose level 6: 40...

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Renal Dose

Renal impairment Mild-to-moderate (CrCl ?30 mL/min): No dose adjustment required; minimally excreted by the kidneys Severe (CrCl <30 mL/min) or hemodialysis: Unknown

Mode of Action

Second-generation orally administered thrombopoietin receptor agonist (TPO-RA) Stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets Does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production

Precaution

Thrombotic/thromboembolic complications Thrombopoietin (TPO) receptor agonists associated with thrombotic and thromboembolic complications in patients with chronic liver disease or chronic ITP Portal vein thrombosis reported with chronic liver disease in patients treated with thrombopoietin (TPO) receptor agonists (ADAPT-1 and ADAPT-2 clinical trials) Consider the potential increased thrombotic risk when administering to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (eg, factor V Leiden, prothrombin 20210A, antithrombin deficiency, or protein C or S deficiency) Not to be administered to patients with chronic liver disease or chronic immune thrombocytopenia in an attempt to normalize platelet counts; thromboembolic events (arterial...

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Side Effect

>10% Pyrexia (8-11%) 1-10% Abdominal pain (6-7%) Nausea (6-7%) Headache (4-7%) Fatigue (3-4%) Peripheral edema (3-4%) <1% Hyponatremia (0.7%)

Pregnancy Category Note

Pregnancy Based on findings from animal reproduction studies, may cause fetal harm when administered to pregnant women In animal reproduction studies, administration resulted in adverse developmental outcomes when administered during organogenesis in rabbits and during organogenesis and the lactation period in rats However, these findings were observed at exposures based on AUC substantially higher than the AUC observed in patients at the recommended dose of 60 mg once daily Advise pregnant women of the potential risk to a fetus Lactation No data are available regarding the presence of the drug in human milk, the effects on the breastfed child, or...

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ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

0 People recently viewed this

Avalet 20

Tablet - (20mg)

Drug International Ltd.

Generic: Avatrombopag

Additional Offers

Cashback

৳100

For purchasing above ৳5000+

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৳80

For purchasing above ৳4000+

Cashback

৳60

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৳40

For purchasing above ৳2000+

Cashback

৳20

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

Avalet 20

Medicine Overview of Avalet 20mg Tablet

Avalet 20

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