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Avalet 20mg Tablet
Avalet 20mg Tablet
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Avalet 20

Tablet - (20mg)
arogga-brand
Drug International Ltd.
Generic: Avatrombopag
Out of Stock
Currently unavailable, please request or choose another variant.
ā§ŗ 2522.87
ā§ŗ 2750
8% OFF

Medicine Overview of Avalet 20mg Tablet

āĻŦāĻžāĻ‚āĻ˛āĻž
English
Indication
Thrombocytopenia
Administration
Take with food
Adult Dose
Thrombocytopenia Patients with chronic liver disease Indicated for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a procedure Taken orally once daily for 5 consecutive days with food Initiate dosing 10-13 days prior to the scheduled procedure Patients should undergo their procedure 5-8 days after the last dose Dose based on preprocedure platelet count Platelet count <40 x10^9/L: 60 mg PO qDay x 5 days Platelet count 40 to <50 x10^9/L: 40 mg PO qDay x 5 days Patients with chronic immune thrombocytopenia Indicated for thrombocytopenia in adults with chronic immune thrombocytopenia (ITP) who have had...
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Renal Dose
Renal impairment Mild-to-moderate (CrCl ?30 mL/min): No dose adjustment required; minimally excreted by the kidneys Severe (CrCl <30 mL/min) or hemodialysis: Unknown
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Mode of Action
Second-generation orally administered thrombopoietin receptor agonist (TPO-RA) Stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets Does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production
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Precaution
Thrombotic/thromboembolic complications Thrombopoietin (TPO) receptor agonists associated with thrombotic and thromboembolic complications in patients with chronic liver disease or chronic ITP Portal vein thrombosis reported with chronic liver disease in patients treated with thrombopoietin (TPO) receptor agonists (ADAPT-1 and ADAPT-2 clinical trials) Consider the potential increased thrombotic risk when administering to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (eg, factor V Leiden, prothrombin 20210A, antithrombin deficiency, or protein C or S deficiency) Not to be administered to patients with chronic liver disease or chronic immune thrombocytopenia in an attempt to normalize platelet counts; thromboembolic events (arterial...
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Side Effect
>10% Pyrexia (8-11%) 1-10% Abdominal pain (6-7%) Nausea (6-7%) Headache (4-7%) Fatigue (3-4%) Peripheral edema (3-4%) <1% Hyponatremia (0.7%)
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Pregnancy Category Note
Pregnancy Based on findings from animal reproduction studies, may cause fetal harm when administered to pregnant women In animal reproduction studies, administration resulted in adverse developmental outcomes when administered during organogenesis in rabbits and during organogenesis and the lactation period in rats However, these findings were observed at exposures based on AUC substantially higher than the AUC observed in patients at the recommended dose of 60 mg once daily Advise pregnant women of the potential risk to a fetus Lactation No data are available regarding the presence of the drug in human milk, the effects on the breastfed child, or...
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Avalet 20

Tablet - (20mg)
arogga-brand
Drug International Ltd.
Generic: Avatrombopag
Out of Stock
Currently unavailable, please request or choose another variant.
ā§ŗ 2522.87
ā§ŗ 2750
8% OFF

Alternative Brands For Avalet 20

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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.