Potential for cardiovascular risk during sexual activity in patients with underlying cardiovascular conditions Monitor patients with left ventricular outflow obstruction (eg, aortic stenosis, idiopathic hypertrophic subaortic stenosis) Dose should not exceed 50 mg/24hr when taking avanafil concomitantly with moderate CYP3A4 inhibitors Initiate therapy at 50 mg/24hr if coadministered with antihypertensive medications like alpha-blockers Priapism may occur especially in patients with predisposed conditions (eg, sickle cell anemia, multiple myeloma, or leukemia) Discontinue therapy if sudden loss of vision in one or both eyes occur (could be a sign of non-arteritic anterior ischemic optic neuropathy) Safety and efficacy not established in patients...
... Show more