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Cozopt
Aristopharma Limited
Generic: Dorzolamide 2% + Timolol 0.5% Eye prep
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Cozopt may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Cozopt is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
To reduce the amount of Cozopt that reaches the breastmilk, place pressure over the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
CONSULT YOUR DOCTOR
It is not known whether Cozopt alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Medicine Overview of Cozopt (2gm+500mg)/100ml Eye Drop
Introduction
Cozopt is a medicine used to reduce pressure in the eyes. This pressure can be caused by or lead to an illness called glaucoma. If the pressure in your eye is too high it can damage your sight. Cozopt works by decreasing the amount of fluid inside the eye. Never use Cozopt if the seal is broken before you use it for the first time. Wash your hands before using it and shake the bottle well before each use. Make sure you remove contact lenses if you wear them and wait for at least 15 minutes before putting them back....
... Show moreUses of Cozopt
- Glaucoma
Side effects of Cozopt
Common
- Headache
- Nausea
- Fatigue
- Burning sensation
- Bitter taste
How to use Cozopt
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
How Cozopt works
Cozopt is a carbonic anhydrase inhibitor. It works by decreasing the production of aqueous humour (fluid in the eye), thereby lowering the increased eye pressure.
What if you forget to take Cozopt?
If you miss a dose of Cozopt, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Cozopt helps lower high pressure in the eye and reduce the risk of vision loss.
- For best results, put one drop 2-3 times daily in the affected eye(s).
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop. This minimizes the risk of side effects.
- Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
- Remove contact lenses before using Cozopt, and wait at least 15 minutes before re-inserting them.
- When applying multiple eye medications, wait for at least 5-15 minutes before delivering the next medication in the same eye to avoid dilution of the medicine.
Brief Description
Indication
Open-angle glaucoma, Ocular hypertension
Adult Dose
Ophthalmic
Ocular hypertension; Open-angle glaucoma
Adult: Instill 1 drop to the affected eye bid.
Child Dose
Ophthalmic
Ocular hypertension; Open-angle glaucoma
2 years
Instill 1 drop to the affected eye bid.
Renal Dose
Renal impairment:
CrCl (ml/min)
<30 Not recommended.
Contraindication
Hypersensitivity to any of the components or sulphonamide. History or current bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, CrClr <30 ml/min and hyperchloraemic acidosis.
Mode of Action
Timolol maleate, a nonselective beta-adrenergic blocker, reduces aqueous humor formation. Dorzolamide, a carbonic anhydrase inhibitor, has actions similar to acetazolamide.
By inhibiting carbonic anhydrase in the ciliary processes of the eye, dorzolamide decreases aqueous humor secretion. Used together, there is additional intraocular pressure reduction compared to using either component alone, but the reduction is not as much as concomitant admin of dorzolamide tid and timolol bid.
Precaution
Hepatic impairment, mild to moderate renal impairment, children <2 yr. Avoid use in pregnancy and lactation. Prinzmetal's angina, cardiac disease, hypotension, myasthenia gravis, history of renal calculi, history of intra-ocular surgery, pre-existing chronic corneal defects. May worsen severe peripheral and central circulatory disorders. May mask symptoms of hypoglycaemia and hyperthyroidism. Withdraw gradually, especially in patients with coronary heart disease. Discontinue treatment at the first signs or symptoms of cardiac failure. Contact lenses to be removed before eyedrop application and wait at least 15 minutes before reinsertion. Apply other eyedrops 10 minutes apart. May affect ability to drive or operate machinery...
... Show moreSide Effect
>10%
Dorzolamide
Ocular burning, stinging, discomfort (33%),Bitter taste (25%),Superficial punctate keratitis (10-15%),Ocular allergic reactions (10%)
Frequency Not Defined
Dorzolamide,Blurred vision,Ocular dryness,Photophobia,Ocular redness,Tearing,Stevens-Johnson syndrome,Toxic epidermal necrolysis
Timolol
Arrythmia,Bradycardia,Syncope,Fatigue,Headache,Dyspnea,Bronchospasm,Chest pain,Edema,Paresthesia,Nausea,Rales,Depression,Decreased exercise tolerance,Raynaud's phenomenon
Potentially Fatal: Cardiac failure, bronchospasm.
Pregnancy Category Note
Pregnancy Category: C
Lactation: Excreted in breast milk; not recommended
Interaction
Additive hypotension and bradycardia with oral calcium channel blockers, catecholamine-depleting drugs or beta-blockers, antiarrhythmics (e.g. amiodarone), digitalis glycosides, parasympathomimetics, narcotics and MAOIs. Additive systemic side effects with oral carbonic anhydrase or beta-blockers; avoid concurrent use. Additive systemic beta-blockade with CYP2D6 inhibitors (e.g. quinidine, SSRIs) and timolol.
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