The dosage of this medication must be lowered if aluminum hydroxide is administered.Amino acid keto analogues should not be taken concurrently with medications that form hardly soluble compounds with calcium, such as tetracyclines, quinolones like ciprofloxacin and norfloxacin, as well as medications containing iron, fluoride, or estramustine, to prevent disrupted absorption of the active ingredient. When consuming these medications and alpha ketoanalogue together, a minimum of two hours should pass.Drugs containing calcium that are administered concurrently may raise or increase serum calcium levels.