Caution is advised when consuming alcohol with Denosis 60. Please consult your doctor.
UNSAFE
Denosis 60 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
SAFE IF PRESCRIBED
Denosis 60 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Denosis 60 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Denosis 60 is safe to use in patients with kidney disease. No dose adjustment of Denosis 60 is recommended.
SAFE IF PRESCRIBED
Denosis 60 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Denosis 60 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Denosis 60mg/ml Injection
Introduction
Denosis 60 is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.
Denosis 60 is given by a healthcare professional and should ... Show more
Uses of Denosis 60
Osteoporosis
Side effects of Denosis 60
Common
Musculoskeletal (bone, muscle or joint) pain
Pain in extremity
Nerve pain
Constipation
Rash
Urinary tract infection
How to use Denosis 60
Your doctor or nurse will guide you how to use this medicine.
How Denosis 60 works
Denosis 60 is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.
What if you forget to take Denosis 60?
If you miss a dose of Denosis 60, please consult your doctor.
Quick Tips
Xgeva Solution for Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Xgeva Solution for Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Xgeva Solution for Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illness ... Show more
Tell your doctor if you develop a rash while taking Xgeva Solution for Injection.
Brief Description
Indication
Osteoporosis, treatment of men and postmenopausal women with osteoporosis who are at high risk for fracture; treatment to increase bone mass in men at ... Show more
Administration
Administer SC in upper arm, upper thigh, or abdomen; do NOT administer intradermally, IM, or IV
Administer calcium and vitamin D as needed to treat o ... Show more
Adult Dose
Denosumab 60mg Subcutaneous
Osteoporosis
60 mg SC every 6 months
Supplement with calcium 1000 mg/day and vitamin D 400 IU/day
Aromatase Inhibit ... Show more
Renal Dose
Renal Impairment: Based on the available safety and efficacy data in the elderly, no dosage adjustment is required in patients with renal impairment.
... Show more
Contraindication
Clinically significant hypersensitivity to denosumab or to any of the components. Hypocalcemia.
Mode of Action
Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to receptor activator of nuclear factor kapp ... Show more
Precaution
Correct hypocalcemia prior to initiation of therapy. Patients should receive Ca & vit D supplements during treatment (unless hypercalcemia is present) ... Show more
Side Effect
>10%
Back pain (34.7%),Extremity pain (11.7%)
1-10%
Musculoskeletal pain (7.6%),Hypercholesterolemia (7.2%),Cystitis (5.9%),Upper respiratory tra ... Show more
Pregnancy Category Note
Pregnancy
Contraindicated
Based on findings in animals and its mechanism of action, denosumab can cause fetal harm when administered to a pregnant ... Show more
Interaction
Increased risk of serious infections w/ immunosuppressive agents.Denosumab did not affect the pharmacokinetics of midazolam, a drug metabolised by cyt ... Show more
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.