It is not known whether it is safe to consume alcohol with Daunobin. Please consult your doctor.
CONSULT YOUR DOCTOR
Daunobin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult...
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UNSAFE
Daunobin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Daunobin may cause side effects which could affect your ability to drive.
CAUTION
Daunobin should be used with caution in patients with kidney disease. Dose adjustment of Daunobin may be needed. Please consult your doctor.
Use of Daunobin is not recommended in patients with severe kidney disease.
CAUTION
Daunobin should be used with caution in patients with liver disease. Dose adjustment of Daunobin may be needed. Please consult your doctor.
Use of Daunobin is not recommended in patients with severe liver disease.
Medicine Overview of Daunobin 20mg/4ml Injection
Introduction
Daunobin is used for the treatment of blood cancer (leukemia). It works by interfering with the growth of cancer cells, which are eventually destroyed.
Daunobin is given under the supervision of a healthcare professional and should not be self-admin...
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Uses of Daunobin
Blood cancer
Side effects of Daunobin
Common
Nausea
Vomiting
Low blood platelets
Ulcer
Abdominal pain
Loss of appetite
Decreased white blood cell count
Hair loss
Fever
Decreased blood cells (red cells, white cells, and platelets)
Fatigue
Anemia (low number of red blood cells)
Chills
Diarrhea
Mucosal inflammation
Febrile neutropenia
Stomatitis (Inflammation of the mouth)
Breathing problems
How to use Daunobin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Daunobin works
Daunobin is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Quick Tips
You must undergo careful examination of functioning of the heart as daunorubicin is known to cause life-threatening heart problems due to da...
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Daunorubicin should be used cautiously is elderly, children, and patients with high blood pressure (manifest arterial hypertension) due to i...
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You may be frequently examined for complete blood-count (blood cells, proteins, hemoglobin), kidney, liver and heart function before and dur...
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Tell your doctor if you have had, have an ongoing or scheduled radiation therapy or X-ray of the chest area. Daunorubicin increases the risk...
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You should be monitored for worsening of infections and development of life-threatening infections (e.g. viral infections like herpes zoster...
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Liposomal preparation of daunorubicin is not recommended for use in children <18 years.
Before starting daunorubicin treatment, make sure that you are free from any side effects of previous chemotherapy (inflammation of the mout...
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Both partners should take extreme care to avoid pregnancy while on daunorubicin therapy and consult your doctor if you get to know that you ...
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Brief Description
Indication
Acute leukaemia, AIDS-related Kaposi's sarcoma
Administration
IV Preparation
Reconstitute 20 mg vial with 4 mL SWI to a final concentration of 5 mg/mL
IV Administration
Vesicant, never administer IM or SC
...
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Adult Dose
Acute Nonlymphocytic Leukemia
In combination with cytarabine 100 mg/m²/day IV for 7 days first course, for 5 days subsequent courses
<60 years ol...
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Child Dose
Acute Nonlymphocytic Leukemia
<2 years old or <0.5 m² BSA: 1 mg/kg IVP qWeek
>2 years old or >0.5 m² BSA: 25 mg/m² IVP qWeek
Acute Lymphocytic L...
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Renal Dose
Renal Impairment
>3 mg/dL serum creatinine: Administer 50% regular dose
Contraindication
Heart failure. Pregnancy, lactation.
Mode of Action
Daunorubicin forms a stable complex with DNA and interferes with the nucleic acid synthesis. It is a cell-cycle nonspecific agent, but its cytotoxic e...
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Precaution
Regular blood count and ECG monitoring; elderly, children. Hepatic or renal impairment may increase risk of toxicity. Pre-existing cardiac disease and...
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Side Effect
>10%
Nausea,Vomiting,Arrhythmias,Discoloration of urine,Alopecia
1-10%
Injection site skin flare,Hyperuricemia,GI ulceration,Diarrhea
<1%
Arr...
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Pregnancy Category Note
Pregnancy Category: D
Lactation: excretion in milk unknown/not recommended
Interaction
Increased risk of cardiotoxicity when used with cyclophosphamide. Increased risk of hepatic toxicity when used with hepatotoxic drugs e.g. high-dose m...
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.