Eluxan 100

Name: Eluxan 100mg Tablet
Brand: Ziska Pharmaceuticals Ltd.
SKU: 6379
Price: 1530 BDT
Availability: InStock
Rating: 4.9 (1 reviews)

Tablet - (100mg)

Ziska Pharmaceuticals Ltd.

Generic: Eluxadoline

Medicine Overview of Eluxan 100mg Tablet

বাংলা

English

Indication

Indicated for diarrhea-predominant, irritable bowel syndrome (IBS-D), in adult men and women

Administration

May be taken with food.

Adult Dose

Irritable Bowel Syndrome Indicated for diarrhea-predominant irritable bowel syndrome (IBS-D) in adult men and women 100 mg PO BID with food Discontinue in patients who develop severe constipation lasting >4 days Hepatic impairment Mild-to-moderate (Child-Pugh A or B): Decrease dose to 75 mg PO BID; monitor for impaired mental or physical abilities needed to perform potentially hazardous activities Severe (Child-Pugh C): Contraindicated

Contraindication

Documented hypersensitivity to drug or components of the formulation Patients who do not have a gallbladder Known or suspected gallbladder obstruction, biliary duct obstruction or sphincter of Oddi disease or dysfunction; increased risk for sphincter of Oddi spasm Alcoholism, alcohol abuse, alcohol addiction, or in patients who drink >3 alcoholic beverages/day; increased risk of pancreatitis History of pancreatitis, pancreatic duct obstruction, or structural diseases of the pancreas; increased risk of acute pancreatitis Severe hepatic impairment (Child-Pugh C); risk of significantly increased eluxadoline plasma concentrations

Mode of Action

Mu opioid receptor agonist; it also is a delta opioid receptor antagonist and a kappa opioid receptor agonist The multiple opioid activity is designed to treat the symptoms of IBS-D while reducing the incidence of constipation that can occur with unopposed mu opioid receptor agonists

Precaution

Eluxadoline is a mu opioid receptor agonist; because of this mechanism of action, the potential for increased risk of sphincter of Oddi spasm exists, resulting in pancreatitis or hepatic enzyme elevation associated with acute abdominal pain In patients with a gallbladder, evaluate a patient’s alcohol intake prior to starting therapy; instruct patients to avoid chronic or acute excessive alcohol use while in therapy; monitor for new or worsening abdominal pain that may radiate to back or shoulder, with or without nausea and vomiting; instruct patients to immediately stop therapy and seek medical attention if they experience symptoms suggestive of pancreatitis...

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Side Effect

1-10% Constipation (7-8%) Nausea (7-8%) Abdominal pain (6-7%) URT infection (3-5%) Vomiting (4%) Nasopharyngitis (3-4%) Abdominal distention (3%) Bronchitis (3%) Dizziness (3%) Flatulence (3%) Rash (3%) Increased ALT (2-3%) Fatigue (2-3%) Viral gastroenteritis (1-3%) <2% Gastrointestinal: GERD General disorders: Feeling drunk Investigations: Increased AST Nervous system: Sedation, somnolence Psychiatric disorders: Euphoric mood Respiratory: Asthma, bronchospasm, respiratory failure, wheezing <1% Severe constipation

Pregnancy Category Note

Pregnancy No studies in pregnant women Animal reproduction studies Oral and SC administration of eluxadoline to rats and rabbits during organogenesis at doses approximately 51 and 115 times the human exposure after a single oral dose of 100 mg, respectively, demonstrated no teratogenic effects. In a prenatal and postnatal development study in rats No adverse effects were observed in offspring with oral administration of eluxadoline at doses approximately 10 times the human exposure Lactation Unknown if distributed in human breast milk Secreted in rat milk Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for...

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Eluxan 100

Tablet - (100mg)

Ziska Pharmaceuticals Ltd.

Generic: Eluxadoline

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.