Enalapril is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Enalapril is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use of Enalapril immediately after childbirth should be avoided.
UNSAFE
Enalapril may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Enalapril should be used with caution in patients with kidney disease. Dose adjustment of Enalapril may be needed. Please consult your doctor.
Regular monitoring of blood pressure, kidney function test, and potassium levels is recommended while you are taking this medicine.
CAUTION
Enalapril should be used with caution in patients with liver disease. Dose adjustment of Enalapril may be needed. Please consult your doctor.
Inform your doctor if you experience fatigue, develop yellowing of the skin and eyes or white stools while taking this medicine.
Medicine Overview of Enalapril 5mg/10mg Tablet
Introduction
Enalapril belongs to a group of medicines known as angiotensin converting enzyme (ACE) inhibitors. It is widely used to treat high blood pressure and heart failure and may be prescribed after a heart attack. It also lowers the chances of having a heart attack or stroke. Enalapril can be prescribed either alone or in combination with other medicines. It should be taken on an empty stomach. This medicine should be taken at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or even if your blood...
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Uses of Enalapril
Hypertension (high blood pressure)
Prevention of heart attack and stroke
Heart failure
Side effects of Enalapril
Common
Decreased blood pressure
Cough
Increased potassium level in blood
Fatigue
Weakness
Dizziness
How to use Enalapril
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Enalapril may be taken with or without food, but it is better to take it at a fixed time.
How Enalapril works
Enalapril is an angiotensin converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.
What if you forget to take Enalapril?
If you miss a dose of Enalapril, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
It should be taken with or without food, preferably at the same time each day.
Enalapril can make you feel dizzy for the first few days, so rise slowly if you have been sitting or lying down. You can also prefer taking it at bedtime to avoid dizziness throughout the day.
Let your doctor know about any cough, or throat irritation that does not go away.
It may increase the level of potassium in blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Hypertension, Heart failure
Administration
May be taken with or without food.
Adult Dose
Hypertension
Oral
Initial: 2.5-5 mg PO qDay
Maintenance: 10-40 mg/day PO qDay or divided q12hr
Left Ventricular Dysfunction
Initial: 2.5 mg PO q12hr
May titrate up to 20 mg/day
Congestive Heart Failure
Initial: 2.5 mg PO qDay or q12hr
Maintenance: 5-40 mg/Day PO divided q12hr; titrate slowly q2Weeks
Hepatic impairment: No dosage adjustment required
Child Dose
Hypertension
1 month to 16 years (oral)
Initial: 0.08 mg/kg/day PO or divided q12hr; not to exceed 5 mg/day
May increase PRN q2Weeks according to blood pressure not to exceed 0.58 mg/kg/day (or 40 mg/day)
Renal Dose
Renal impairment
CrCl <30 mL/min: (PO) Initiate 2.5 mg; titrate to response; not to exceed 40 mg
Dialysis: 2.5 mg PO on day of dialysis; adjust dose on nondialysis days according to BP
CrCl <30 mL/min: (IV) Initiate 0.625 mg q6hr; titrate based on response
CrCl ?30 mL/min: (PO) Initiate 5 mg/day; titrate to maximum of 40 mg
CrCl ?30 mL/min: (IV) 1.25 mg q6hr; titrate based on response
Contraindication
Hypersensitivity. History of angioedema due to previous treatment with ACE inhibitors; bilateral renal artery stenosis. Pregnancy.
Mode of Action
Enalapril, a prodrug of enalaprilat, competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion. This promotes vasodilation and BP reduction.
Precaution
Impaired renal function. Hyperkalaemia, hypovolaemia, collagen vascular disease, valvular stenosis, during or immediately before or after anaesthesia, unilateral renal artery stenosis. Hypotension due to volume depletion, diuretic therapy. Monitor WBC count. Lactation, children.
Side Effect
1-10%
Dizziness (4-8%),Hypotension (0.9-6.7%),Headache (2-5%),Chest pain (2%),Cough (1-2%),Rash (1.5%)
Frequency Not Defined
Asthenia,Nausea,Vomiting,Hyperkalemia
Potentially Fatal: Angioedema.
Pregnancy Category Note
Pregnancy May cause fetal harm when administered to a pregnant woman; use of drugs that act on renin-angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death; when pregnancy is detected, discontinue therapy as soon as possible Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (e.g., need for cesarean section, and post-partum hemorrhage); hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly Lactation Enalapril and enalaprilat have been detected...
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Interaction
May potentiate hypotensive action w/ diuretics, other antihypertensives, TCAs, nitrates or anaesth. Concomitant admin w/ lithium carbonate may cause lithium toxicity. Increased risk of renal impairment w/ NSAIDs. May increase hyperkalaemic effect w/ K-sparing diuretics and supplements.
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.