Itopride Hydrochloride should be administered with care when co-administered with the following drugs: Anticholinergic Drugs, Tiquizium bromide, Scopolamine butyl bromide, Timepidium bromide, etc. Sign: There is a possibility of reducing the activity of Itopride Hydrochloride which activates gastrointestinal motility (cholinergic action). Mechanism & risc factor: Gastrointestinal motility inhibitory action of Anticholinergic pharmacologically decreases the activity of the drug.