>10%
Thrombocytopenia (12-46%),Anemia (44%),Diarrhea (43%),Rash/desquamation (40%),Fatigue (37%),Abd pain (31%),Hand-foot skin reaction (30%),Weight loss (30%),Anorexia (29%),Alopecia (27%),Nausea (24%),Lymphopenia (23%),Neutropenia (18%),Hemorrhage (15-18%),Hypertension (9-17%),Vomiting (16%),Constipation (15%),Neuropathy (13%),Dry skin (11%)
1-10%
Headache (10%),Joint pain (10%),Congestive heart failure, MI (1.9%),QT prolonation (rare)
<1%
Acute renal failure,Angioedema and arrhythmia may occur,Bone pain reported
Frequency Not Defined
Stevens-Johnson Syndrome,Hyperthyroidism,Interstitial lung disease
Potentially Fatal: Bleeding fatalities. Hypertensive crisis.