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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Defera 500. Please consult your doctor.
CONSULT YOUR DOCTOR
Defera 500 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Defera 500 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
CONSULT YOUR DOCTOR
It is not known whether Defera 500 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CONSULT YOUR DOCTOR
There is limited information available on the use of Defera 500 in patients with kidney disease. Please consult your doctor.
Regular monitoring of kidney function tests is advised in these patients while taking this medicine.
CONSULT YOUR DOCTOR
There is limited information available on the use of Defera 500 in patients with liver disease. Please consult your doctor.
Regular monitoring of liver function tests is advised in patients with liver disease while taking this medicine.
Medicine Overview of Defera 500mg tablet
Introduction
Defera 500 is a medicine used in the treatment of chronic iron overload caused due to frequent blood transfusion. It helps removes excess iron and reduces the risk of it causing organ damage.
Defera 500 should be taken in empty stomach. Take it regularly at a fixed time each day to get the maximum benefit of the medicine.
Using of Defera 500 may cause common side effects such as nausea, headache, constipation, diarrhea and increased liver enzyme. If the side effects persist or worsen, inform your doctor.
Uses of Defera 500
- Iron overload
- Transfusion dependent thalassemia
Side effects of Defera 500
Common
- Fatigue
- Headache
- Nausea
- Vomiting
- Abdominal pain
- Joint pain
- Diarrhea
How to use Defera 500
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Defera 500 may be taken with or without food, but it is better to take it at a fixed time.
How Defera 500 works
Defera 500 traps and removes excess iron which is then excreted mainly in the stools. This reduces the risk of organ damage.
What if you forget to take Defera 500?
If you miss a dose of Defera 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Seek immediate medical attention if you see symptoms of fever, sore throat, or flu as deferiprone can cause neutropenia (a decrease in white blood cells) or agranulocytosis (abnormal decrease in white blood cell count).
- Take precautions as deferiprone can lower the ability of your body to fight infections. Your blood will need to be tested weekly while you are taking this medication.
- Deferiprone may result in urine that is reddish-brown in color. This side effect is normal and usually not harmful.
- Take medical advice if you also have upper stomach pain, clay-colored stools, or jaundice (yellowing of your skin or the whites of your eyes).
- Tell your doctor if you suffer from dizziness, palpitations, light-headedness, syncope, or seizures after taking deferiprone.
Brief Description
Indication
Thalassaemia, Iron overload
Administration
May be taken with or without food.
Adult Dose
Transfusional Iron Overload
Iron chelator indicated for treatment of transfusional iron overload caused by thalassemia syndromes when current chelation therapy is inadequate
25-33 mg/kg PO TID (ie, total daily dosage range 75-99 mg/kg/day)
Round dose to nearest 250 mg
Contraindication
Agranulocytosis, pregnancy and lactation.
Mode of Action
Deferiprone is an orally effective iron-chelating agent. It is being used when desferrioxamine is unsuitable or contraindicated.
Precaution
Hepatic and renal impairment. Neutropenia, monitor neutrophil count wkly and discontinue treatment if neutropenia develops. Limited experience in children 6-10 yr.
Lactation: Unknown whether distributed in breast milk; because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Side Effect
>10%
Chromaturia (14.6%),Nausea (12.6%),Abdominal pain/discomfort (10.4%)
1-10%
Arthralgia (9.8%),Vomiting (9.8%),Increased ALT (7.5%),Decreased neutrophil count (7.3%),Neutropenia (6.2%),Increased appetite (4%),Diarrhea (3%),Headache (2.5%),Dyspepsia (2%),Back pain (2%),Extremity pain (1.9%),Increased weight (1.9%),Agranulocytosis (1.7%),Arthropathy (1.4%),Increased AST (1.2%),Decreased appetite (1.1%)
Pregnancy Category Note
Pregnancy Limited available data with use in pregnant women are insufficient to inform a drug-associated risk of major birth defects and miscarriage Verify the pregnancy status of females of reproductive potential prior to initiating therapy Contraception Females: Advise females of reproductive potential to avoid pregnancy during treatment and 6 months of contraception is recommended after cessation of therapy; advise females to immediately report pregnancy Males: Advise males with female sexual partners of reproductive potential to use effective contraception during treatment and 3 months of contraception is recommended after cessation of therapy Lactation There is no information regarding the presence of...
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Avoid using deferiprone with aluminium-containing antacids as it can chelates trivalent metal ions.
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