ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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Square Pharmaceuticals PLC.
Generic: Ambrisentan
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Ambrisan 5. Please consult your doctor.
UNSAFE
Ambrisan 5 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Information regarding the use of Ambrisan 5 during breastfeeding is not available. Please consult your doctor.
CAUTION
Ambrisan 5 may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
CAUTION
Ambrisan 5 should be used with caution in patients with severe kidney disease. Dose adjustment of Ambrisan 5 may be needed. Please consult your doctor.
Limited information is available on use of Ambrisan 5 in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
CAUTION
Ambrisan 5 should be used with caution in patients with liver disease. Dose adjustment of Ambrisan 5 may be needed. Please consult your doctor.
Medicine Overview of Ambrisan 5mg Tablet
Introduction
Ambrisan 5 is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression. This medication may be taken with or without food and It is better to take it in a dose and duration as advised by the doctor. In case, you have missed any dose than it is better to take another one as soon as you remember it. Dizziness may occur as its side effect, so do not...
... Show moreUses of Ambrisan 5
- Pulmonary arterial hypertension (PAH)
Side effects of Ambrisan 5
Common
- Headache
- Dizziness
- Palpitations
- Breathlessness
- Runny nose
- Feeling sick
- Diarrhea
- Fatigue
How to use Ambrisan 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ambrisan 5 may be taken with or without food, but it is better to take it at a fixed time.
How Ambrisan 5 works
Ambrisan 5 is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Ambrisan 5 helps relax these blood vessels and increases the supply of blood to the lungs.
What if you forget to take Ambrisan 5?
If you miss a dose of Ambrisan 5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Ambrisan 5 to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
- It helps improve your quality of life, exercising ability, and delay disease progression.
- Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
- Do not drive or do anything requiring concentration until you know how Ambrisan 5 affects you.
- Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
- Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Ambrisan 5 as it is toxic to an unborn baby.
- Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Brief Description
Indication
Pulmonary Arterial Hypertension
Administration
May be taken with or without food: Swallow whole.
Adult Dose
Indicated for WHO group 1 PAH to 1) improve exercise ability and delay clinical worsening; and 2) in combination with tadalafil to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability
Initiate treatment at 5 mg PO qDay, with or without tadalafil 20 mg PO qDay
At 4-week intervals, either ambrisentan or tadalafil dose can be increased, as needed and tolerated, not to exceed ambrisentan 10 mg/day or tadalafil 40 mg/day
Coadministration with cyclosporine: Limit ambrisentan to 5 mg/day
Hepatic impairment: Ambrisentan is not recommended in patients with moderate or severe hepatic impairment.
Child Dose
Safety and efficacy not established
Renal Dose
Dose adjustment in patients with mild or moderate renal impairment is therefore not required. There is no information on the exposure to ambrisentan in patients with severe renal impairment.
Contraindication
Ambrisentan may cause fetal harm when administered to a pregnant woman. Ambrisentan is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus. Pregnancy must be excluded before the initiation of treatment with Ambrisentan and prevented during treatment and for one month after stopping treatment. Ambrisentan is contraindicated in patients with Idiopathic Pulmonary Fibrosis (IPF) including IPF patients with pulmonary hypertension (WHO Group 3).
Mode of Action
High affinity endothelin (ETa) receptor subtype antagonist, resulting in inhibition of vasoconstriction.
Precaution
Fluid Retention: Peripheral oedema has been observed with ERAs including ambrisentan. It is also a clinical consequence of PAH and worsening PAH.
Pulmonary Veno-occlusive Disease: If patients develop acute pulmonary edema during initiation of therapy with vasodilating agents such as Ambrisentan, the possibility of pulmonary veno-occlusive disease should be considered, and if confirmed. Ambrisentan should be discontinued.
Hematological Changes: Decreases in hemoglobin concentration and hematocrit have followed administration of other endothelin receptor antagonists and were observed in clinical studies with Ambrisentan.
Lactation: Excretion in milk unknown; not recommended
Side Effect
>10%
Peripheral edema (17%),Headache (15%)
1-10%
Nasal congestion (6%),Palpitations (5%),Constipation (4%),Dyspnea (4%),Flushing (4%),Abdominal pain (3%),Nasopharyngitis (3%),Sinusitis (3%)
Pregnancy Category Note
Pregnancy Based on data from animal reproduction studies, fetal harm may occur when administered to a pregnant woman and is contraindicated during pregnancy There are limited data on use in pregnant women Advise patient of the potential hazard to a fetus Animal data In animal reproduction studies, ambrisentan was teratogenic in rats and rabbits at doses which resulted in exposures of 3.5 and 1.7 times, respectively, the human dose of 10 mg/day Contraception Female patients of reproductive potential must use acceptable methods of contraception during treatment and for 1 month after stopping treatment Patients should choose one highly effective form...
... Show moreInteraction
Cyclosporine
Exposure to ambrisentan may be increased (approximately 2-fold). Limit the dosage of ambrisentan to 5 mg daily with coadministration.
Rifampin
Coadministration was associated with a 2-fold increase in ambrisentan AUC. Use with caution.
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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Square Pharmaceuticals PLC.
Generic: Ambrisentan
Additional Offers
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৳100
For purchasing above ৳5000+
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৳60
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৳40
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৳20
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.
