Out of stock
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
Popular Pharmaceuticals Ltd.
Generic: Fosphenytoin Sodium
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Fosfen.
CONSULT YOUR DOCTOR
Fosfen is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Fosfen is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Please consult your doctor.
UNSAFE
Fosfen may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Fosfen should be used with caution in patients with kidney disease. Dose adjustment of Fosfen may be needed. Please consult your doctor.
However, talk to your doctor if you have any underlying kidney disease.
CAUTION
Fosfen should be used with caution in patients with liver disease. Dose adjustment of Fosfen may be needed. Please consult your doctor.
Medicine Overview of Fosfen 2ml Injection
Introduction
Fosfen is a prescription medicine used for the treatment of epilepsy (seizures). It controls seizures by decreasing the abnormal and excessive activity of the nerve cells in the brain. Fosfen is given under the supervision of a healthcare professional and should not be self administered. You should never skip any doses and finish the full course of treatment even if you feel better as stopping the medication without talking to the doctor may cause non-stop seizures and can endanger life. Be careful if you are using birth control pills as this medicine may interfere with the working of contraceptives. Fosfen...
... Show moreUses of Fosfen
- Epilepsy/Seizures
Side effects of Fosfen
Common
- Vomiting
- Sleepiness
- Dizziness
- Itching
- Impaired coordination
- Nystagmus (involuntary eye movement)
How to use Fosfen
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Fosfen works
Fosfen is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Fosfen?
If you miss a dose of Fosfen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- It is given as an injection either into a vein (intravenously) or into a muscle (intramuscularly).
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- It may increase blood sugar levels.Inform your doctor if you are taking any medicines to treat diabetes.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Brief Description
Indication
Fosphenytoin is indicated for short-term parenteral administration when other means of Phenytoin administration are unavailable, inappropriate or deemed less advantageous. Fosphenytoin can be used for the control of, generalized convulsive status epilepticus, prevention and treatment of seizures, occurring during neurosurgery or head injury. It can also be substituted, short-term, for oral Phenytoin.
Administration
Reconstitution:
Prior to IV infusion, dilute Fosphenytoin in 5% Dextrose or 0.9% Saline solution for injection to a concentration ranging from 1.5 to 25 mg PE/ml.
Adult Dose
Parenteral Adult: As phenytoin Na equivalents (PSE): (The dose, concentration in dosing solutions, and infusion rate of IV Fosphenytoin is expressed as Phenytoin Sodium equivalents (PE); (Fosphenytoin Sodium 1.5 mg equivalent to Phenytoin Sodium 1 mg) to avoid the need to perform molecular weight-based adjustments when converting between Fosphenytoin and Phenytoin Sodium doses.) Status Epilepticus: By intravenous infusion (at a rate of 100-150 mg (PE)/minute), initially 15 mg (P/E)/kg then By intramuscular injection or By intravenous infusion (at a rate of 50-100 mg (PE)/minute), 4-5 mg (P/E)/kg daily in 1-2 divided doses, Prophylaxis or treatment of seizures associated with neurosurgery...
... Show moreChild Dose
Parenteral As phenytoin Na equivalents (PSE): (The dose, concentration in dosing solutions, and infusion rate of IV Fosphenytoin is expressed as Phenytoin Sodium equivalents (PE); (Fosphenytoin Sodium 1.5 mg equivalent to Phenytoin Sodium 1 mg) to avoid the need to perform molecular weight-based adjustments when converting between Fosphenytoin and Phenytoin Sodium doses.) Status Epilepticus: Child >5 years: By intravenous infusion (at a rate of 2-3 mg (PE)/kg/minute), initially 15 mg (PE)/kg then By intravenous infusion (at a rate of 1-2 mg (PE)/kg/minute), 4-5 mg (PE)/kg daily in 1-4 divided doses, Prophylaxis or treatment of seizures associated with neurosurgery or head...
... Show moreRenal Dose
Renal impairment: Dose reduction or slower infusion may be needed.
Contraindication
Fosphenytoin is contraindicated in patients who have demonstrated hypersensitivity to Fosphenytoin or its ingredients, or to Phenytoin or other Hydantoins. Fosphenytoin is also contraindicated in patients with sinus bradycardia, sino-atrial block, second and third degree A-V block, and Adams-Stokes syndrome.
Mode of Action
Fosphenytoin is a diphosphate ester salt of phenytoin which acts as a water soluble prodrug of phenytoin. After admin, plasma esterases convert fosphenytoin to phosphate, formaldehyde, and phenytoin as the active moiety; phenytoin stabilises neuronal membranes and decreases seizure activity by increasing efflux or decreasing influx of Na ions across cell membranes in the motor cortex during generation of nerve impulses.
Precaution
Patient w/ phosphate restriction, hypoalbuminaemia, hypotension, severe myocardial insufficiency, DM. May exacerbate porphyria. Not effective for the treatment of absence seizures and seizures associated w/ hypoglycaemia or other metabolic causes. Avoid abrupt withdrawal. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor BP, cardiac and resp function; vital signs, haematologic and hepatic function, plasma phenytoin concentrations.
Side Effect
>10% IV Pruritis (40-50%),Dizziness (31%),Somnolence (20%),Ataxia (11%) IM Nystagmus (15%) 1-10% IV Tinnitus (6-10%),Deafness (2-5%) IM Somnolence (6-10%),Bruising (7%),Pruritis (2-5%),Nausea (5%),Vomiting (3%),Weakness (4%) 1%) Frequency Not Defined Hypotension (esp with high rates of IV infusion) Hypertension Dysarthria Fever Increased reflex Intracranial HTN Hypesthesia Sensory disturbances (burning, itching, paresthesia), withdrawal-precipitated seizures Rash Constipation Hypokalemia Cytopenias (can be fatal) Hepatic injury Myasthenia Pneumonia IV Hypotension, vasodilation, tachycardia Agitation, asthenia, headache, EPS, paresthesia, stupor, tremor Dry mouth, nausea, vomiting Pelvic and back pain Diplopia, nystagmus Body as a Whole: Allergic reactions in the form of rash and rarely more serious forms (DRESS) or...
... Show morePregnancy Category Note
Pregnancy In humans, prenatal exposure to phenytoin (the active metabolite of fosphenytoin) may increase risks for congenital malformations and other adverse development outcomes; an increased incidence of major malformations (such as orofacial clefts and cardiac defects) and abnormalities characteristic of fetal hydantoin syndrome (dysmorphic skull and facial features, nail and digit hypoplasia, growth abnormalities [including microcephaly], and cognitive deficits) reported among children born to epileptic women who took phenytoin alone or in combination with other antiepileptic drugs during pregnancy; there have been several reported cases of malignancies, including neuroblastoma, in children whose mothers received phenytoin during pregnancy Lactation It is...
... Show moreInteraction
No drugs are known to interfere with the conversion of Fosphenytoin to Phenytoin. Drugs that may increase plasma Phenytoin concentrations include: Acute alcohol intake, Amiodarone, Chloramphenicol, Chlordiazepoxide, Cimetidine, Diazepam, Dicumarol, Disulfiram, Estrogens, Ethosuximide, Fluoxetine, H2-Antagonists, Halothane, Isoniazid, Methylphenidate, Phenothiazines, Phenylbutazone, Salicylates, Succinimides, Sulfonamides, Tolbutamide, Trazodone. Drugs that may decrease plasma phenytoin concentrations include: Carbamazepine, chronic alcohol abuse, Reserpine. Drugs that may either increase or decrease plasma Phenytoin concentrations include: Phenobarbital, Valproic Acid, and Sodium Valproate. Similarly, the effects of Phenytoin on Phenobarbital, Valproic Acid and Sodium plasma Valproate concentrations are unpredictable. Potentially Fatal: May cause loss of virologic response and...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
Popular Pharmaceuticals Ltd.
Generic: Fosphenytoin Sodium
Additional Offers
Cashback
৳100
For purchasing above ৳5000+
Cashback
৳80
For purchasing above ৳4000+
Cashback
৳60
For purchasing above ৳3000+
Cashback
৳40
For purchasing above ৳2000+
Cashback
৳20
For purchasing above ৳1000+
Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.