12-24 Hours
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Gefinix 250
Beacon Pharmaceuticals PLC
Generic: Gefitinib
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Gefinix 250.
CONSULT YOUR DOCTOR
Gefinix 250 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Gefinix 250 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Gefinix 250 may cause side effects which could affect your ability to drive.
Gefinix 250 may make you feel weak. This may affect your driving ability.
CAUTION
Gefinix 250 should be used with caution in patients with severe kidney disease. Dose adjustment of Gefinix 250 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Gefinix 250 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Gefinix 250 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Gefinix 250mg Tablet
Introduction
Gefinix 250 is used in the treatment of non-small cell lung cancer. It is used in patients in which it has spread to other parts of the body, who have abnormal epidermal growth factor receptor (EGFR) genes, and who have not had previous treatment for cancer. Gefinix 250 can be taken with or without food, but better to have it same time every day for better results. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. You should take it exactly as...
... Show moreUses of Gefinix 250
- Non-small cell lung cancer
Side effects of Gefinix 250
Common
- Diarrhea
- Dry skin
- Loss of appetite
- Nausea
- Rash
- Stomatitis (Inflammation of the mouth)
- Vomiting
- Weakness
How to use Gefinix 250
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gefinix 250 may be taken with or without food, but it is better to take it at a fixed time.
How Gefinix 250 works
Gefinix 250 is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
What if you forget to take Gefinix 250?
If you miss a dose of Gefinix 250, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Gefinix 250 helps treat non-small cell lung cancer that is locally advanced, or has spread to other areas of the body.
- Take it with or without food, preferably at the same time each day.
- Do not take antacids (to reduce the acid level of your stomach) 2 hours before or 1 hour after taking this medicine.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- Inform your doctor if you develop ulceration in your mouth, changes in your vision or if you experience a worsening cough, shortness of breath, or breathing difficulties while taking this medicine.
- Your doctor may want you to have regular blood tests to monitor your liver function while you are having treatment with this medicine.
Brief Description
Indication
Non-small Cell Lung Cancer
Administration
Film-coated tab: May be taken with or without food. May also be dispersed in ½ glass of plain, non-carbonated water. No other liqd should be used. Drop the tab in water & stir w/o crushing until it disperses (approx 10 min). Drink immediately. Rinse glass w/ another ½ glass of water & drink. Dispersed liqd may also be administered via NG tube.
Adult Dose
Oral
Locally advanced or metastatic non-small cell lung carcinoma
Adult: 250 mg once daily until disease progression or unacceptable toxicity
Contraindication
Hypersensitivity. Lactation.
Mode of Action
Gefitinib is a synthetic anilinoquinazoline which inhibits the intracellular phosphorylation of numerous tyrosine kinases associated w/ transmembrane cell surface receptors found on both normal and cancer cells, including epidermal growth factor receptor (EGFR) tyrosine kinase. Tyrosine kinase activity appears to be essentially important to cell proliferation and survival.
Precaution
Patients w/ concurrent idiopathic pulmonary fibrosis, acute onset or worsening pulmonary or eye symptoms. Renal and hepatic impairment. Pregnancy. Monitoring Parameters Monitor liver function, prothrombin time or INR frequently.
Lactation
Unknown if distributed in human breast milk; not recommended
Side Effect
>10% Skin reactions, all grades (47%),Diarrhea, all grades (29%),Decreased appetite, all grades (17%),Vomiting, all grades (14%),Increased ALT, all grades (11.4%) 1-10% Increased AST, all grades (7.9%),Stomatitis, all grades (7%),Conjunctivitis, blepharitis, and dry eye (6.7%),Conjunctivitis/blepharitis/dry eye (6%),Increased ALT, grades 3-4 (5.1%),Nail disorders, all grades (5%),Diarrhea, grades 3-4 (3%),Increased AST, grades 3-4 (3%),Increased bilirubin, all grades (2.7%),Decreased appetite, grades 2-3 (2.3%),Skin reactions, grades 3-4 (2%),Interstitial lung disease, all grades (1.3%),Vomiting, grades 3-4 (1.2%) <1% Interstitial lung disease, grades 3-4 (0.7%),Increased bilirubin, grades 3-4 (0.7%),Stomatitis, all grades (0.3%),Corneal erosion and aberrant eyelash growth (0.2%),Nail disorders, grades 3-4 (0.1%),Gastrointestinal perforation (0.1%),Ocular keratitis (0.1%),Erythema multiforme...
... Show moreInteraction
Concomitant use w/ CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine, barbiturates) may reduce serum gefitinib levels. Plasma concentrations may be increased w/ potent CYP3A4 inhibitors (e.g. itraconazole, ketoconazole). Increased INR or bleeding events w/ warfarin. May increase plasma levels of metoprolol. May exacerbate vinorelbine-induced neutropenia. Decreased plasma levels and potential reduction in efficacy w/ drugs that affect gastric pH (e.g. PPIs, H2-receptor antagonists).
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