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Karvela 800
Healthcare Pharmaceuticals Ltd.
Generic: Sevelamer Hydrochloride/Carbonate
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Karvela 800. Please consult your doctor.
CONSULT YOUR DOCTOR
Karvela 800 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Karvela 800 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Karvela 800 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Karvela 800 is safe to use in patients with kidney disease. No dose adjustment of Karvela 800 is recommended.
However, regular monitoring of calcium levels is advisable in these patients.
SAFE IF PRESCRIBED
Karvela 800 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Karvela 800 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Karvela 800mg Tablet
Introduction
Karvela 800 is used to treat increased phosphate level in the blood. It is used in patients who are on dialysis due to severe kidney disease. It inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood. Karvela 800 should be taken with food. Take it in the dose and duration as advised by your doctor. Take it regularly and at a fixed time each day to get maximum benefit of the medicine. Using of Karvela 800 may cause side effects such as nausea, vomiting, abdominal pain, constipation and diarrhea. You may also develop...
... Show moreUses of Karvela 800
- High phosphate levels in blood
Side effects of Karvela 800
Common
- Nausea
- Vomiting
- Upper abdominal pain
- Flatulence
- Constipation
- Diarrhea
How to use Karvela 800
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Karvela 800 is to be taken with food.
How Karvela 800 works
Karvela 800 inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood.
What if you forget to take Karvela 800?
If you miss a dose of Karvela 800, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Karvela 800 is used to control blood phosphate level in patients that are on dialysis treatment.
- You must take it with food and stick to the diet prescribed by your doctor.
- You may develop low levels of calcium, folic acid, and vitamins A,D,E, and K in your blood. Your doctor may prescribe supplements, if necessary.
- Avoid taking any other medicine 1 hour before or 3 hours after taking Karvela 800.
- Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.
Brief Description
Indication
Hyperphosphataemia
Administration
Should be taken with food.
Adult Dose
End-Stage Renal Disease Hemodialysis; hyperphosphatemia Initial dose Serum PO4 >9 mg/dL [2.91 mmol/L]: 1600 mg PO q8hr with meals Serum PO4 7.5-9 mg/dL [2.42-2.91 mmol/L]: 1200-1600 mg PO q8hr with meals Serum PO4 5.5-7.5 mg/dL [1.78-2.42 mmol/L]: 800 mg PO q8hr with meals Maintenance dose Serum PO4 >5.5 mg/dL [>1.78 mmol/L]: Increase dose by 400-800 mg per meal Serum PO4 3.5-5.5 mg/dL [1.13-1.78 mmol/L]: Maintain current dose Serum PO4 <3.5 mg/dL [1.13 mmol/L] decrease by 400-800 mg per meal Dosing considerations Titrate dose; increase by 400-800 mg per meal at 2-week intervals; no more than 4 g Switching From Ca-Acetate...
... Show moreChild Dose
Safety and efficacy not established
Contraindication
Hypophosphatemia or bowel obstruction.
Mode of Action
Sevelamer, a polymeric compound, acts by binding to phosphate molecules in the gut, limiting its absorption and thus lowering serum phosphate levels w/o altering Ca, Al, or bicarbonate levels.
Precaution
Patients w/ dysphagia, swallowing disorders, severe GI motility disorders, active inflammatory bowel disease or major GI tract surgery. Pregnancy and lactation. Monitoring Parameters Monitor serum levels of phosphate, Ca, Cl and bicarbonate. Vitamin supplementation due to reduction in vit D, E, K and folic acid absorption. Monitor for signs and symptoms of peritonitis in patients undergoing peritoneal dialysis.
Lactation: Not absorbed systemically; not excreted in breast milk
Side Effect
>10%
Vomiting (22%),Nausea (20%),Diarrhea (19%),Dyspepsia (16%),Nasopharyngitis (14%),Limb pain (13%),Pruritus (13%),Arthralgia (12%),Bronchitis (11%),Dyspnea (10%),Hypertension (10%)
1-10%
Abdominal pain (9%),Constipation (8%),Flatulence (8%),Peritonitis (during peritoneal dialysis: 8%),Hypercalcemia (5-7%)
Frequency Not Defined
Back pain,Cough,Headache,Pyrexia,Upper respiratory infection,Pruritus,Rash,Intestinal perforation,Fecal impaction,Intestinal obstruction.
Interaction
May decrease absorption of ciprofloxacin, ciclosporin, mycophenolate, tacrolimus and levothyroxine. Sevelamer should be given 3 hr before or 1 hr after taking other drugs to minimise potential pharmacokinetic interaction.
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