Caution is advised when consuming alcohol with G-Methotrexate. Please consult your doctor.
UNSAFE
G-Methotrexate is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
G-Methotrexate is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
G-Methotrexate may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
G-Methotrexate should be used with caution in patients with kidney disease. Dose adjustment of G-Methotrexate may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
CAUTION
G-Methotrexate should be used with caution in patients with liver disease. Dose adjustment of G-Methotrexate may be needed. Please consult your doctor.
Use of G-Methotrexate is not recommended in patients with severe liver disease.
Medicine Overview of G-Methotrexate 2.5mg Tablet
Introduction
G-Methotrexate is a medicine used to treat rheumatoid arthritis where it can prevent further joint damage. It is also used to treat severe forms of a skin disease called psoriasis by killing cells in the skin which are growing too quickly.
G-Methotr...
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Uses of G-Methotrexate
Rheumatoid arthritis
Psoriasis
Side effects of G-Methotrexate
Common
Abdominal pain
Indigestion
Loss of appetite
Nausea
Vomiting
Tiredness
Mouth sore
How to use G-Methotrexate
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. G-Methotrexate may be taken with or without food, but it is better to take it at a fixed time.
How G-Methotrexate works
G-Methotrexate is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the r...
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Quick Tips
Take it once a week, on the same day every week.
Drink plenty of liquids to stay hydrated while taking this medication.
Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
It may take 6 to 8 weeks for G-Methotrexate to work. Keep taking the medication as prescribed.
Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Should be taken on an empty stomach. Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort. Avoid taking w/ milk-rich products...
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Adult Dose
Adult:
PO
Burkitt's lymphoma 10-25 mg/day for 4-8 days, repeat after 7-10 days.
Choriocarcinoma 15-30 mg/day for 5 days, repeat after an interva...
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Child Dose
Polyarticular Juvenile Idiopathic Arthritis
Initial: 10 mg/m² PO/IM/SC qWeek
Meningeal Leukemia
<1 year: 6 mg intrathecally (IT) every 2-5 days
1-2 years: 8 mg IT every 2-5 days
2-3 years: 10 mg IT every 2-5 days
>3 years: 12 mg IT every 2-5 days
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
61-80 75% of dose
51-60 70% of dose
10-50 30-50% of dose
<10 Avoid use
Intermittent hemo...
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Contraindication
Severe renal or hepatic impairment, pre-existing profound bone marrow suppression in patients with psoriasis or rheumatoid arthritis, alcoholic liver ...
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Mode of Action
Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of red...
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Precaution
Hepatic or renal impairment, bone marrow depression, elderly, neonates. Ulcerative disorders of the GI tract. Monitor haematological, renal and hepati...
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Side Effect
>10%
Arachnoiditis with intrathecal administration,Subacute toxicity with intrathecal administration (paralysis of extremities, cranial nerve palsy, ...
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Interaction
Decreased effectiveness with folic acid and its derivatives.
Potentially Fatal: Increased toxicity with NSAIDs and salicylates; probenecid; some pe...
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.